α-Mangostin mitigates age-associated metabolic disorders targeting adipose tissue inflammation

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	α-Mangostin mitigates age-associated metabolic disorders targeting adipose tissue inflammation
	Li Dan; Liu Qianyu; Wang Yitao; LIN LIGEN
	2019
Size of Audience	60
Type of Speaker	invited talk
Abstract	Obesity and its related metabolic disorders are highly prevalent in the elderly individuals. Low-grade chronic adipose tissue inflammation contributes to the onset and development of age-related insulin resistance and type 2 diabetes. There’s still lack of effective therapy for treatment of age-related metabolic disorders. The present study identified that α-mangostin (α-Man), a xanthone from Garcinia mangostana, remodels adipose tissue inflammation to mitigate age-related metabolic disorders. α-Man protected the mice against lipopolysaccharides (LPS)-induced acute adipose tissue inflammation, by reducing the expression of pro-inflammatory cytokines and chemokines and inhibiting the migration of macrophages into the adipose tissue and the pro-inflammatory polarization of macrophages. In a cohort of young (3-month) and old (18‒20 month) mice, α-Man mitigated age-associated adiposity, hyperlipidemia, and insulin resistance. α-Man alleviated age-related adipose tissue inflammation by reducing macrophage infiltration and pro-inflammatory polarization in visceral adipose tissue. Moreover, α-Man protected the old mice against liver injury through suppressing the secretion of microRNA-155-5p from macrophages. The above results demonstrate that α-Man, targeting adipose tissue inflammation, might represent a novel candidate to treat aging-related metabolic disorders and extend health-span.
Source Publication	5th IUPHAR World Conference of Pharmacology on Natural Products
Conference Place	Hyderabad, India
Document Type	Presentation
Collection	Institute of Chinese Medical Sciences
Corresponding Author	LIN LIGEN
Affiliation	University of Macau
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Li Dan,Liu Qianyu,Wang Yitao,et al. α-Mangostin mitigates age-associated metabolic disorders targeting adipose tissue inflammation[Z]. 5th IUPHAR World Conference of Pharmacology on Natural Products

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