In this paper, a finite difference (FD) scheme based on time two-grid algorithm is proposed for solving the two-dimensional time-fractional Fisher equation (2D-TFFE). Firstly, the Caputo fractional derivative and the spatial derivative are discretized by the 𝐿⁢2−1𝜎 formula and the central difference formula, respectively. In order to improve the efficiency of computation, the time two-grid algorithm is then constructed. Secondly, based on the cut-off function technic, stability and convergence of the time two-grid FD scheme are obtained by the energy method, and the global convergence order is O⁢(𝜏²_𝐹+𝜏⁴_𝐶+ℎ²_𝑥+ℎ²_𝑦) (Formula presented.), where  𝜏_𝐹  and  and 𝜏_𝐶 represent time-step sizes on the fine and coarse grid, respectively, while ℎ_𝑥 and ℎ_𝑦 represent the space-step sizes. Finally, numerical experiments are presented to show the feasibility and efficiency of the algorithm.