| Residential College | false |
| Status | 已發表Published |
| OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage | |
Zhong, Yunxiao1,2; Zhang, Xinya1,2; Feng, Ruibing1; Fan, Yu1,2; Zhang, Zhang3,4; Zhang, Qing Wen1; Wan, Jian Bo1 ; Wang, Yitao1; Yu, Hua1; Li, Guodong1,2
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| 2024-11-01 | |
| Source Publication | Medicinal Research Reviews
 |
| ISSN | 0198-6325 |
| Volume | 44Issue:6Pages:2825-2848 |
| Abstract | Oxidative DNA damage-related diseases, such as incurable inflammation, malignant tumors, and age-related disorders, present significant challenges in modern medicine due to their complex molecular mechanisms and limitations in identifying effective treatment targets. Recently, 8-oxoguanine DNA glycosylase 1 (OGG1) has emerged as a promising multifunctional therapeutic target for the treatment of these challenging diseases. In this review, we systematically summarize the multiple functions and mechanisms of OGG1, including pro-inflammatory, tumorigenic, and aging regulatory mechanisms. We also highlight the potential of OGG1 inhibitors and activators as potent therapeutic agents for the aforementioned life-limiting diseases. We conclude that OGG1 serves as a multifunctional hub; the inhibition of OGG1 may provide a novel approach for preventing and treating inflammation and cancer, and the activation of OGG1 could be a strategy for preventing age-related disorders. Furthermore, we provide an extensive overview of successful applications of OGG1 regulation in treating inflammatory, cancerous, and aging-related diseases. Finally, we discuss the current challenges and future directions of OGG1 as an emerging multifunctional therapeutic marker for the aforementioned challenging diseases. The aim of this review is to provide a robust reference for scientific researchers and clinical drug developers in the development of novel clinical targeted drugs for life-limiting diseases, especially for incurable inflammation, malignant tumors, and age-related disorders. |
| Keyword | 8-oxoguanine DNA glycosylase 1 age-related disorders inflammation oxidative DNA damage-related diseases tumors |
| DOI | 10.1002/med.22068 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85200797575 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | 1.Macao Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 2.Zhuhai UM Science and Technology Research Institute, Zhuhai, China 3.International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MoE) of People's Republic of China, College of Pharmacy, Jinan University, Guangzhou, China 4.Modernization and Innovative Drug Discovery of Chinese Ministry of Education, Guangzhou City Key Laboratory of Precision Chemical Drug Development, School of Pharmacy, Jinan University, Guangzhou, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Zhong, Yunxiao,Zhang, Xinya,Feng, Ruibing,et al. OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage[J]. Medicinal Research Reviews, 2024, 44(6), 2825-2848. |
| APA | Zhong, Yunxiao., Zhang, Xinya., Feng, Ruibing., Fan, Yu., Zhang, Zhang., Zhang, Qing Wen., Wan, Jian Bo., Wang, Yitao., Yu, Hua., & Li, Guodong (2024). OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage. Medicinal Research Reviews, 44(6), 2825-2848. |
| MLA | Zhong, Yunxiao,et al."OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage".Medicinal Research Reviews 44.6(2024):2825-2848. |
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