Nick Groom develops his earlier work on the influence of The Vampyre on Mary Shelley's novel Frankenstein. Both were conceived at the Villa Diodati during the summer of 1816, and Frankenstein has deep affinities with the vampire lore that was evidently aired during conversations between Lord, Byron, Percy Shelley, Mary Godwin (later Shelley), Claire Clairmont, and Polidori. But the influence was also reciprocal, and Frankenstein echoes through Polidori's tale in unexpected ways. The character Aubrey has often been seen as a self-portrait of Polidori while it is generally accepted that the vampire Lord Ruthven is an audacious attack on Byron, who employed Polidori as his personal physician. However, in this chapter Groom presents a radical and unsettling close reading of the character of Aubrey, informed by Mary Shelley's presentation of Victor Frankenstein, arguing that the relationship between Aubrey and Ruthven is far more complex and uncanny than has hitherto been recognised.