Residential College | false |
Status | 已發表Published |
H-Bonds Enhanced Natural Polyphenols Bined Polysaccharide/Gelatin Composites with Controlled Photothermal Stimulation Phase Transition for Wound Care | |
Chen, Chonghao1,2; Zhang, Junbo1; Zhong, Guofeng1; Lei, Pengkun1; Qin, Xuhua1; Zhang, Chen1![]() ![]() ![]() | |
2024-09-13 | |
Source Publication | Biomaterials Research
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ISSN | 1226-4601 |
Volume | 28Pages:0082 |
Abstract | Severe open wounds should be closed immediately and regularly undergo re-examination and debridement.Therefore, dressings should effectively cover the wound, creating a moist environment for healing whilemeeting mechanical requirements for daily movement and adaptability. Herein, a low-cost and easy-to-prepare plant polysaccharide hydrogel was reported. The Mesona chinensis Benth polysaccharidestrengthened the hydrogel network by hydrogen bonding and changed the phase transition temperature,but retained the thermal response characteristics of the hydrogel. By adjusting the polysaccharideconcentration, MepGel(1) can be prepared to remain stable as a semisolid at body temperature andtransform into a shear-thinning semifluid state when appropriately heated. The composite hydrogel couldbe easily shaped, effectively closing wounds of different shapes, while maintaining excellent mechanicalproperties. Importantly, this composite hydrogel had a near-infrared photothermal effect resulting inexcellent antibacterial effect and collided with its own thermal response producing functions conducive towound care, like accelerating the self-healing of the dressing, achieving re-adhesion, and further coveringthe wound. Furthermore, the hydrogel had excellent biocompatibility, enhancing immunity and promotinghealing of bacterial-infected wounds. The low cost and rich functionality demonstrated by MepGel had thepotential to face the enormous challenges and economic burden of clinical wound healing. |
DOI | 10.34133/bmr.0082 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Engineering ; Materials Science |
WOS Subject | Engineering, Biomedical ; Materials Science, bioMaterials |
WOS ID | WOS:001313999100001 |
Publisher | AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
Scopus ID | 2-s2.0-85207626370 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
Corresponding Author | Zhang, Chen; Zeng, Rui; Qu, Yan |
Affiliation | 1.State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China 3.College of Pharmacy, Southwest Minzu University, Chengdu 610041, China 4.Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Chengdu 610041, China |
First Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Chen, Chonghao,Zhang, Junbo,Zhong, Guofeng,et al. H-Bonds Enhanced Natural Polyphenols Bined Polysaccharide/Gelatin Composites with Controlled Photothermal Stimulation Phase Transition for Wound Care[J]. Biomaterials Research, 2024, 28, 0082. |
APA | Chen, Chonghao., Zhang, Junbo., Zhong, Guofeng., Lei, Pengkun., Qin, Xuhua., Zhang, Chen., Zeng, Rui., & Qu, Yan (2024). H-Bonds Enhanced Natural Polyphenols Bined Polysaccharide/Gelatin Composites with Controlled Photothermal Stimulation Phase Transition for Wound Care. Biomaterials Research, 28, 0082. |
MLA | Chen, Chonghao,et al."H-Bonds Enhanced Natural Polyphenols Bined Polysaccharide/Gelatin Composites with Controlled Photothermal Stimulation Phase Transition for Wound Care".Biomaterials Research 28(2024):0082. |
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