| Residential College | false |
| Status | 即將出版Forthcoming |
| International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis | |
Chen, Xin1; Tsvetkov, Andrey S.2; Shen, Han Ming3 ; Isidoro, Ciro4; Ktistakis, Nicholas T.5; Linkermann, Andreas6,7; Koopman, Werner J.H.8,9; Simon, Hans Uwe10,11; Galluzzi, Lorenzo12,13,14; Luo, Shouqing15; Xu, Daqian16; Gu, Wei17; Peulen, Olivier18; Cai, Qian19; Rubinsztein, David C.20,21; Chi, Jen Tsan22; Zhang, Donna D.23; Li, Changfeng24; Toyokuni, Shinya25,26; Liu, Jinbao27; Roh, Jong Lyel28; Dai, Enyong29; Juhasz, Gabor30,31; Liu, Wei32; Zhang, Jianhua33; Yang, Minghua34,35; Liu, Jiao36; Zhu, Ling Qiang37; Zou, Weiping38; Piacentini, Mauro39,40; Ding, Wen Xing41; Yue, Zhenyu42; Xie, Yangchun43; Petersen, Morten44; Gewirtz, David A.45; Mandell, Michael A.46; Chu, Charleen T.47; Sinha, Debasish48; Eftekharpour, Eftekhar49,84; Zhivotovsky, Boris50,51,52; Besteiro, Sébastien53,85; Gabrilovich, Dmitry I.54; Kim, Do Hyung55; Kagan, Valerian E.56; Bayir, Hülya57; Chen, Guang Chao58; Ayton, Scott59; Lünemann, Jan D.60; Komatsu, Masaaki61; Krautwald, Stefan62; Loos, Ben63; Baehrecke, Eric H.64; Wang, Jiayi65,66,67; Lane, Jon D.68; Sadoshima, Junichi69; Yang, Wan Seok70; Gao, Minghui71; Münz, Christian72; Thumm, Michael73; Kampmann, Martin74,75; Yu, Di76,77; Lipinski, Marta M.78; Jones, Jace W.79; Jiang, Xuejun80; Zeh, Herbert J.81; Kang, Rui81; Klionsky, Daniel J.82; Kroemer, Guido83,84,85; Tang, Daolin81
| |
| 2024 | |
| Source Publication | Autophagy
 |
| ISSN | 1554-8627 |
| Volume | 20Issue:6Pages:1213-1246 |
| Abstract | Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results. Abbreviation: 3-MA:3-methyladenine; 4HNE: 4-hydroxynonenal; ACD: accidentalcell death; ADF: autophagy-dependentferroptosis; ARE: antioxidant response element; BH2:dihydrobiopterin; BH4: tetrahydrobiopterin; BMDMs: bonemarrow-derived macrophages; CMA: chaperone-mediated autophagy; CQ:chloroquine; DAMPs: danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR: electronparamagnetic resonance; ER, endoplasmic reticulum; FRET: Försterresonance energy transfer; GFP: green fluorescent protein;GSH: glutathione;IF: immunofluorescence; IHC: immunohistochemistry; IOP, intraocularpressure; IRI: ischemia-reperfusion injury; LAA: linoleamide alkyne;MDA: malondialdehyde; PGSK: Phen Green™ SK;RCD: regulatedcell death; PUFAs: polyunsaturated fatty acids; RFP: red fluorescentprotein;ROS: reactive oxygen species; TBA: thiobarbituricacid; TBARS: thiobarbituric acid reactive substances; TEM:transmission electron microscopy. |
| Keyword | Cell death ferritinophagy iron lipid peroxidation lipophagy lysosome |
| DOI | 10.1080/15548627.2024.2319901 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85189958829 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Affiliation | 1.Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China 2.Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, United States 3.Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macao 4.Department of Health Sciences, University of Piemonte Orientale, Novara, Italy 5.Babraham Institute, Cambridge, United Kingdom 6.Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany 7.Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, United States 8.Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands 9.Human and Animal Physiology, Wageningen University, Wageningen, Netherlands 10.Institute of Pharmacology, University of Bern, Bern, Switzerland 11.Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany 12.Department of Radiation Oncology, Weill Cornell Medical College, New York, United States 13.Sandra and Edward Meyer Cancer Center, New York, United States 14.Caryl and Israel Englander Institute for Precision Medicine, New York, United States 15.Peninsula Medical School, University of Plymouth, Plymouth, United Kingdom 16.Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China 17.Institute for Cancer Genetics, Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, United States 18.Metastasis Research Laboratory, GIGA Cancer-University of Liège, Liège, Belgium 19.Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, United States 20.Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom 21.UK Dementia Research Institute, University of Cambridge, Cambridge, United Kingdom 22.Department of Molecular Genetics and Microbiology, Duke University, Durham, United States 23.Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, Tucson, United States 24.Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, China 25.Department of Pathology and Biological Response, Nagoya University Graduate School of Medicine, Nagoya, Japan 26.Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan 27.Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China 28.Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, South Korea 29.The Second Department of Hematology and Oncology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China 30.Biological Research Center, Institute of Genetics, Szeged, Hungary 31.Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary 32.Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, China 33.Department of Pathology, University of Alabama at Birmingham, Birmingham, United States 34.Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China 35.Hunan Clinical Research Center of Pediatric Cancer, Changsha, China 36.DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China 37.Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 38.Departments of Surgery and Pathology, University of Michigan Medical School, Ann Arbor, United States 39.Department of Biology, University of Rome “Tor Vergata”, Rome, Italy 40.National Institute for Infectious Diseases IRCCS “Lazzaro Spallanzani”, Rome, Italy 41.Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, United States 42.Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States 43.Department of Oncology, Central South University, Changsha, Hunan, China 44.Functional genomics, Department of Biology, Copenhagen University, Denmark 45.Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Richmond, United States 46.Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, United States 47.Pathology, University of Pittsburgh School of Medicine, Pittsburgh, United States 48.Department of Ophthalmology, University of Pittsburgh, The Johns Hopkins University School of Medicine, Baltimore, United States 49.Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada 50.Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 51.Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russian Federation 52.Engelhardt Institute of Molecular Biology, Moscow, Russian Federation 53.LPHI, University Montpellier, CNRS, Montpellier, France 54.AstraZeneca, Early Oncology R&D, Gaithersburg, United States 55.Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, United States 56.Department of Environmental Health, University of Pittsburgh, Pittsburgh, United States 57.Department of Pediatrics, Columbia University, New York, United States 58.Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan 59.Florey Institute, University of Melbourne, Parkville, Australia 60.Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany 61.Department of Physiology, Juntendo University School of Medicine, Bunkyo-ku Tokyo, Japan 62.Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel, Germany 63.Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa 64.Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, United States 65.Department of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 66.Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 67.College of Medical Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China 68.School of Biochemistry, University of Bristol, Bristol, United Kingdom 69.Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, United States 70.Department of Biological Sciences, St. John’s University, New York City, United States 71.The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China 72.Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland 73.Department of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany 74.Department of Biochemistry & Biophysics, University of California, San Francisco, United States 75.Institute for Neurodegenerative Diseases, University of California, San Francisco, United States 76.Faculty of Medicine, Frazer Institute, University of Queensland, Brisbane, Australia 77.Faculty of Medicine, Ian Frazer Centre for Children’s Immunotherapy Research, Child Health Research Centre, University of Queensland, Brisbane, Australia 78.Department of Anesthesiology & Department of Neurobiology, University of Maryland School of Medicine, Baltimore, United States 79.Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, United States 80.Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States 81.Department of Surgery, UT Southwestern Medical Center, Dallas, United States 82.Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States 83.Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France 84.Metabolomics and Cell Biology Platforms, Villejuif, France 85.Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France |
| Recommended Citation GB/T 7714 | Chen, Xin,Tsvetkov, Andrey S.,Shen, Han Ming,et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis[J]. Autophagy, 2024, 20(6), 1213-1246. |
| APA | Chen, Xin., Tsvetkov, Andrey S.., Shen, Han Ming., Isidoro, Ciro., Ktistakis, Nicholas T.., Linkermann, Andreas., Koopman, Werner J.H.., Simon, Hans Uwe., Galluzzi, Lorenzo., Luo, Shouqing., Xu, Daqian., Gu, Wei., Peulen, Olivier., Cai, Qian., Rubinsztein, David C.., Chi, Jen Tsan., Zhang, Donna D.., Li, Changfeng., Toyokuni, Shinya., ...& Tang, Daolin (2024). International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy, 20(6), 1213-1246. |
| MLA | Chen, Xin,et al."International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis".Autophagy 20.6(2024):1213-1246. |
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