Mesenchymal stromal cell therapies for traumatic neurological injuries

doi:10.1186/s12967-024-05725-3

Residential College	false
Status	已發表Published
	Mesenchymal stromal cell therapies for traumatic neurological injuries
	Wang, Xiujuan 1; Wang, Qian 2,3; Xia, Ziyao 4,5; Yang, Ying 1; Dai, Xunan 5; Zhang, Chun 4,5; Wang, Jiaxian 2,3; Xu, Yongsheng 1,5
	2024-12-01
Source Publication	Journal of Translational Medicine
Volume	22 Issue:1
Abstract	Improved treatment options are urgently needed for neurological injuries resulting from trauma or iatrogenic events causing long-term disabilities that severely impact patients’ quality of life. In vitro and animal studies have provided promising proof-of-concept examples of regenerative therapies using mesenchymal stromal cells (MSC) for a wide range of pathological conditions. Over the previous decade, various MSC-based therapies have been investigated in clinical trials to treat traumatic neurological injuries. However, while the safety and feasibility of MSC treatments has been established, the patient outcomes in these studies have not demonstrated significant success in the translation of MSC regenerative therapy for the treatment of human brain and spinal cord injuries. Herein, we have reviewed the literature and ongoing registered trials on the application of MSC for the treatment of traumatic brain injury, traumatic spinal cord injury, and peripheral nerve injury. We have focused on the shortcomings and technological hurdles that must be overcome to further advance clinical research to phase 3 trials, and we discuss recent advancements that represent potential solutions to these obstacles to progress.
Keyword	Mesenchymal stem cells Neurological injury Peripheral nerve injury Spinal cord injury Traumatic brain injury
DOI	10.1186/s12967-024-05725-3
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85209740549
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Technology Department, Tianjin Everunion Biotechnology Co., Ltd, SOHO Nexus Center, Beijing, No. 19A East 3rd Ring North Road, Chaoyang District, 100020, China 2.HELP Therapeutics Co., Ltd, Nanjing, No. 568 Longmian Avenue, Jiangning District, Jiangsu Province, 211166, China 3.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, E12 Avenida da Universidade, SAR, 519000, Macao 4.Department of Ophthalmology, Peking University Third Hospital, Beijing, No. 49 North Garden Road, Haidian District, 100191, China 5.Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, No. 49 North Garden Road, Haidian District, 100191, China
Recommended Citation GB/T 7714	Wang, Xiujuan,Wang, Qian,Xia, Ziyao,et al. Mesenchymal stromal cell therapies for traumatic neurological injuries[J]. Journal of Translational Medicine, 2024, 22(1).
APA	Wang, Xiujuan., Wang, Qian., Xia, Ziyao., Yang, Ying., Dai, Xunan., Zhang, Chun., Wang, Jiaxian., & Xu, Yongsheng (2024). Mesenchymal stromal cell therapies for traumatic neurological injuries. Journal of Translational Medicine, 22(1).
MLA	Wang, Xiujuan,et al."Mesenchymal stromal cell therapies for traumatic neurological injuries".Journal of Translational Medicine 22.1(2024).

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