Osteoarthritis (OA) is a progressively developing condition primarilycharacterized by the deterioration of articular cartilage and the proliferation ofbone, along with ongoing inflammation. Although the precise pathogenesisremains somewhat elusive, restoring the homeostatic balance of theintra-articular microenvironment is crucial for the management of OA.Intra-articular injection of medication is one of the most direct and effectivetreatment methods; however, most injectable drugs used for osteoarthritistreatment, due to their rapid breakdown, quick release, poor biological activity,and frequent injections, leading to increased risk of infection and suboptimaltherapeutic outcomes. In this study, a lubricating and dual-responsiveinjectable hydrogel based on zeolitic imidazolate frameworks-8 (ZIF-8)impregnated with Quercetin (Que) is designed, which can facilitate OAtreatment by remodeling the microenvironment. The prepared injectablenanocomposite hydrogel (MH/CCM@ZIF-8@Que) exhibits pH and reactiveoxygen species (ROS) responsiveness, alongside a controllable release ofbioactive substances to modulate the microenvironment of bone tissue,thereby mitigating synovitis and the degeneration of cartilage matrix, whilesimultaneously facilitating cartilage repair. This developed thermosensitiveinjectable hydrogel, which effectively balances lubrication with the controlledrelease of bioactive substances, represents a highly promising therapeuticapproach for osteoarthritis.