GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma

doi:10.1016/j.mtbio.2024.101434

Residential College	false
Status	即將出版Forthcoming
	GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma
	Sun, Yi 1; Li, Enze 2; Zhong, Wenzhao 2; Deng, Zhaoming 1; Zhou, Ziyao 1; Wong, Ka Hong 2; Li, Xiangwei 1
	2025-02-01
Source Publication	Materials Today Bio
Volume	30
Abstract	Oral squamous cell carcinoma (OSCC) remains a formidable challenge due to high recurrence rates and limited efficacy of conventional treatments. Immunotherapy holds potential, but its effectiveness is often restricted by low patient responsiveness. This study presents a novel therapeutic strategy using GSH/pH-responsive copper-based cascade nanocomplexes to induce immunogenic cell death (ICD) in OSCC. The fabricated nanocomplex, PC@B-H, leverages the acidic and reducing tumor microenvironment to release copper ions and plumbagin, triggering a cascade of cell death mechanisms including cuproptosis, ferroptosis, and necroptosis. This multifunctional system not only enhances oxidative stress but also depletes glutathione, promotes lipid peroxidation, and disrupts mitochondrial function, leading to robust tumor inhibition. Additionally, the induction of ICD facilitates dendritic cell maturation and cytotoxic T lymphocyte infiltration, providing durable anti-tumor immunity. The study demonstrates that PC@B-H achieves a 92.3 % tumor growth inhibition rate with minimal systemic toxicity, offering a promising avenue for enhancing the efficacy of OSCC treatment through combined cell death pathways and immune activation.
Keyword	Cuproptosis Ferroptosis Immunogenic cell death Necroptosis Oral squamous cell carcinomas
DOI	10.1016/j.mtbio.2024.101434
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85213527381
Fulltext Access	View Full-Text via DOI View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Stomatology Department, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
Recommended Citation GB/T 7714	Sun, Yi,Li, Enze,Zhong, Wenzhao,et al. GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma[J]. Materials Today Bio, 2025, 30.
APA	Sun, Yi., Li, Enze., Zhong, Wenzhao., Deng, Zhaoming., Zhou, Ziyao., Wong, Ka Hong., & Li, Xiangwei (2025). GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma. Materials Today Bio, 30.
MLA	Sun, Yi,et al."GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma".Materials Today Bio 30(2025).

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