| Residential College | false |
| Status | 即將出版Forthcoming |
| Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial | |
Gu, Li Mei1,2; Deng, Can Jin1,2; Shang, De Wei1,2; Huang, Shan Qing1,2; Nie, Sha1,2; Yang, Xin Hu1,2; Ning, Yu Ping1,2; Huang, Xing Bing1,2; Balbuena, Lloyd3; Xiang, Yu Tao4,5 ; Zheng, Wei1,2
| |
| 2025-02-01 | |
| Source Publication | Journal of Affective Disorders
 |
| ISSN | 0165-0327 |
| Volume | 370Pages:190-197 |
| Abstract | Background: A few sham-controlled studies have examined the efficacy, safety, and tolerability of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in adolescents with first-episode major depressive disorder (FE-MDD). Methods: Forty adolescents (aged 13–17 years) with FE-MDD were randomly assigned to receive active rTMS (n = 20) or sham rTMS (n = 20) for 10 sessions over two weeks. The severity of baseline depressive symptoms and their improvement on the day immediately after the second, fourth, sixth, eighth, and tenth sessions were assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17). Results: After completing 10 rTMS treatment sessions, there was no significant difference in antidepressant response (70.0 % vs. 60.0 %, p > 0.05) and antidepressant remission (55.0 % vs. 35.0 %, p > 0.05) between rTMS groups. The linear mixed model analysis did not show a significant group-by-time interaction (F = 1.26; p > 0.05) in the HAMD-17 scores. There was a significant time main effect on the speed of processing (F = 13.61; p < 0.05), but this did not differ significantly between groups (p > 0.05). There were no other main effects and group-by-time interactions in the other MATRICS Consensus Cognitive Battery domains (all p > 0.05). All adverse event categories, such as fatigue and headache, were similar in the two groups (all p > 0.05). Conclusions: In this study that compared a combination of LF-rTMS + medication with sham + medication, LF-rTMS had higher response and remission rates than a sham procedure in adolescents with FE-MDD, but the change was not statistically significant. LF-rTMS is generally safe, with mild adverse effects and no negative impact on neurocognitive performance for adolescents with FE-MDD. Registration number: ChiCTR2000037878. |
| Keyword | Adolescents First-episode Low-frequency Major depressive disorder rTMS |
| DOI | 10.1016/j.jad.2024.11.001 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85208327118 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION |
| Affiliation | 1.The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China 2.Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China 3.Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada 4.Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China 5.Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China |
| Recommended Citation GB/T 7714 | Gu, Li Mei,Deng, Can Jin,Shang, De Wei,et al. Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial[J]. Journal of Affective Disorders, 2025, 370, 190-197. |
| APA | Gu, Li Mei., Deng, Can Jin., Shang, De Wei., Huang, Shan Qing., Nie, Sha., Yang, Xin Hu., Ning, Yu Ping., Huang, Xing Bing., Balbuena, Lloyd., Xiang, Yu Tao., & Zheng, Wei (2025). Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial. Journal of Affective Disorders, 370, 190-197. |
| MLA | Gu, Li Mei,et al."Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial".Journal of Affective Disorders 370(2025):190-197. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment