| Residential College | false |
| Status | 已發表Published |
| Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study | |
| Lin, Chun1; Lin, Yueh Pin2; Park, Seon Cheol3,4; Jang, Ok Jin5; Si, Tian Mei6; Xiang, Yu Tao7; Lin, Huang Li8; Javed, Afzal9; Sayeed Khan, M. Nasar10; Grover, Sandeep11; Kallivayali, Roy Abraham12; Chee, Kok Yoon13; Kato, Takahiro A.14; Pariwatcharakul, Pornjira15; Maramis, Margarita16; Seneviratne, Lakmi17; Sim, Kang18; Tang, Wai Kwong19; Oo, Tin20; Sartorius, Norman21; Tan, Chay Hoon22; Mian-Yoon, 23; Shinfuku, Naotaka24; Lin, Shih Ku2,8 | |
| 2025 | |
| Source Publication | Asian Journal of Psychiatry
 |
| ISSN | 1876-2018 |
| Volume | 103 |
| Abstract | Aims: This study aimed to assess treatment patterns and the effectiveness of long-acting injectable antipsychotics (LAIs) in patients with bipolar disorder (BD) across various Asian countries. The study focused on comparing the choices of LAIs, other psychotropic medications, and their psychotropic drug load to explore real-world usage and evaluate the potential benefits of LAIs in BD treatment across different countries. Methods: A retrospective cohort study was conducted with BD patients diagnosed according to ICD-10-CM codes F31.0 to F31.9 across 13 Asian countries or regions. Data were collected through an online system covering prescriptions for all psychotropic medications including LAIs. The Anatomical Therapeutic Chemical (ATC) Classification System was used to compare medication dosage patterns. Results: The study analyzed 2029 prescription records for BD, including 103 cases involving LAIs. The highest LAI prescription rates were found in Sri Lanka and Malaysia, with no reported use in Myanmar, India, and Japan. Patients receiving LAIs were younger, more often male, and had higher BMI and drug loads compared to those on oral medications. South Korea and Indonesia showed the highest LAIs drug load. South Korea, Pakistan, and China exhibited the highest total psychotropic drug loads, while Malaysia had the lowest. Conclusions: This study is the first to examine LAIs use for BD across Asia. Cross-national differences in LAIs prescriptions and psychotropic drug load highlight variations in treatment practices and healthcare systems. These findings underscore the need for further research and the development of region-specific guidelines to improve BD treatment outcomes. |
| Keyword | Antipsychotic Bipolar disorder Long-acting injectable Psychotropic drug load REAP |
| DOI | 10.1016/j.ajp.2024.104338 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85211243394 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Kunming Prevention and Control Center, Taipei City Hospital and Psychiatric Center, Taipei, Taiwan 2.Department of Psychiatry, Taipei City Hospital and Psychiatric Center, Taipei, Taiwan 3.Department of Psychiatry, Hanyang University Guri Hospital, Guri, South Korea 4.Department of Psychiatry, Hanyang University College of Medicine, Seoul, South Korea 5.Department of Psychiatry, Bugok National Hospital, Changyeong, South Korea 6.Peking University Sixth Hospital, Beijing, China 7.Unit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences & Centre for Cognitive and Brain Sciences, University of Macau, Macao 8.Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan 9.Pakistan Psychiatric Research Centre, Fountain House, Lahore, Pakistan 10.Department of Psychiatry, Services Hospital, Lahore, Pakistan 11.Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India 12.Pushpagiri Institute of Medical Sciences, Tiruvalla, India 13.Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia 14.Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 15.Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 16.Department of Psychiatry, Dr. Soetomo Hospital - Faculty of Medicine, Airlangga University, Surabaya, Indonesia 17.Department of Psychiatry, University of Sri Jayewardenepura, Sri Lanka 18.Institute of Mental Health, Buangkok Green Medical Park, Singapore 19.Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, China 20.Mental Health Hospital, Yangon University of Medicine, Yangon, Myanmar 21.Association for the Improvement of Mental Health Programs, Geneva, Switzerland 22.Department of Pharmacology, National University of Singapore, Singapore 23.Health Management International, Singapore; Regency Specialist Hospital, Johor, Malaysia 24.School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan |
| Recommended Citation GB/T 7714 | Lin, Chun,Lin, Yueh Pin,Park, Seon Cheol,et al. Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study[J]. Asian Journal of Psychiatry, 2025, 103. |
| APA | Lin, Chun., Lin, Yueh Pin., Park, Seon Cheol., Jang, Ok Jin., Si, Tian Mei., Xiang, Yu Tao., Lin, Huang Li., Javed, Afzal., Sayeed Khan, M. Nasar., Grover, Sandeep., Kallivayali, Roy Abraham., Chee, Kok Yoon., Kato, Takahiro A.., Pariwatcharakul, Pornjira., Maramis, Margarita., Seneviratne, Lakmi., Sim, Kang., Tang, Wai Kwong., Oo, Tin., ...& Lin, Shih Ku (2025). Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study. Asian Journal of Psychiatry, 103. |
| MLA | Lin, Chun,et al."Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study".Asian Journal of Psychiatry 103(2025). |
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