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Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity
Zhang, Yue1; Yang, Xuehan1; Zhao, Yawei1; Chen, Fangman4; Shi, Tongfei2; Wu, Ziping2; Chen, Xuenian3; Zhang, Ming1; Chen, Li1
2025
Source PublicationColloids and Surfaces B: Biointerfaces
ISSN0927-7765
Volume245Pages:114308
Abstract

The global crisis of antibiotic resistance has impelled the exigency to develop more effective drug delivery systems for the treatment of bacterial infection. The development of possessing high biocompatibility and targeted delivery of antimicrobials remains a persisting challenge. For programmable release of efficient antimicrobials in infection sites to enhance antibacterial activity, herein, we fabricated diselenide-bridged mesoporous organosilica nanoparticle-supported silver nanoparticles (Ag NPs) with high drug-loading capacity for the co-delivery of tobramycin (TOB) within one drug delivery system (Ag-MON@TOB (Se)). The resultant Ag-MON@TOB (Se) exhibited favorable biocompatibility due to its high stability in the physiological condition. Notably, such Ag-MON@TOB (Se) manifested a programmable structural destabilization to trigger sequential drug release in response to the oxidative stimuli within the bacterial infection microenvironment. In contradistinction to the oxidation-stable disulfide bond moieties within the framework of the nanocarrier (Ag-MON@TOB (S)), the Ag-MON@TOB (Se) with its programmed drug release behavior augmented prominent antibacterial therapy both in vitro and in vivo. This work represents a promising strategy for programmable drug release by harnessing a responsive degradable vehicle to enhance the treatment of bacterial infection.

KeywordDrug Release Mesoporous Organosilica Nanocarriers Nanoantibiotics Responsive Degradation Silver Nanoparticles
DOI10.1016/j.colsurfb.2024.114308
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, bioMaterials
WOS IDWOS:001337161500001
PublisherELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
Scopus ID2-s2.0-85206069129
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen, Fangman; Zhang, Ming; Chen, Li
Affiliation1.Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China
2.School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong, 511442, China
3.School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, Yue,Yang, Xuehan,Zhao, Yawei,et al. Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity[J]. Colloids and Surfaces B: Biointerfaces, 2025, 245, 114308.
APA Zhang, Yue., Yang, Xuehan., Zhao, Yawei., Chen, Fangman., Shi, Tongfei., Wu, Ziping., Chen, Xuenian., Zhang, Ming., & Chen, Li (2025). Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity. Colloids and Surfaces B: Biointerfaces, 245, 114308.
MLA Zhang, Yue,et al."Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity".Colloids and Surfaces B: Biointerfaces 245(2025):114308.
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