Residential College | false |
Status | 已發表Published |
Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity | |
Zhang, Yue1; Yang, Xuehan1; Zhao, Yawei1; Chen, Fangman4; Shi, Tongfei2; Wu, Ziping2; Chen, Xuenian3; Zhang, Ming1; Chen, Li1 | |
2025 | |
Source Publication | Colloids and Surfaces B: Biointerfaces |
ISSN | 0927-7765 |
Volume | 245Pages:114308 |
Abstract | The global crisis of antibiotic resistance has impelled the exigency to develop more effective drug delivery systems for the treatment of bacterial infection. The development of possessing high biocompatibility and targeted delivery of antimicrobials remains a persisting challenge. For programmable release of efficient antimicrobials in infection sites to enhance antibacterial activity, herein, we fabricated diselenide-bridged mesoporous organosilica nanoparticle-supported silver nanoparticles (Ag NPs) with high drug-loading capacity for the co-delivery of tobramycin (TOB) within one drug delivery system (Ag-MON@TOB (Se)). The resultant Ag-MON@TOB (Se) exhibited favorable biocompatibility due to its high stability in the physiological condition. Notably, such Ag-MON@TOB (Se) manifested a programmable structural destabilization to trigger sequential drug release in response to the oxidative stimuli within the bacterial infection microenvironment. In contradistinction to the oxidation-stable disulfide bond moieties within the framework of the nanocarrier (Ag-MON@TOB (S)), the Ag-MON@TOB (Se) with its programmed drug release behavior augmented prominent antibacterial therapy both in vitro and in vivo. This work represents a promising strategy for programmable drug release by harnessing a responsive degradable vehicle to enhance the treatment of bacterial infection. |
Keyword | Drug Release Mesoporous Organosilica Nanocarriers Nanoantibiotics Responsive Degradation Silver Nanoparticles |
DOI | 10.1016/j.colsurfb.2024.114308 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Biophysics ; Chemistry ; Materials Science |
WOS Subject | Biophysics ; Chemistry, Physical ; Materials Science, bioMaterials |
WOS ID | WOS:001337161500001 |
Publisher | ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS |
Scopus ID | 2-s2.0-85206069129 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | University of Macau |
Corresponding Author | Chen, Fangman; Zhang, Ming; Chen, Li |
Affiliation | 1.Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China 2.School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong, 511442, China 3.School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, China 4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Zhang, Yue,Yang, Xuehan,Zhao, Yawei,et al. Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity[J]. Colloids and Surfaces B: Biointerfaces, 2025, 245, 114308. |
APA | Zhang, Yue., Yang, Xuehan., Zhao, Yawei., Chen, Fangman., Shi, Tongfei., Wu, Ziping., Chen, Xuenian., Zhang, Ming., & Chen, Li (2025). Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity. Colloids and Surfaces B: Biointerfaces, 245, 114308. |
MLA | Zhang, Yue,et al."Redox-responsive degradation of antimicrobials with programmable drug release for enhanced antibacterial activity".Colloids and Surfaces B: Biointerfaces 245(2025):114308. |
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