A meaningful e-marketplace (MEMP) is a common business information space where computer agents can faithfully deliver the true meanings of e-trade with each other on behalf of their human masters. Partial understanding of any received e-trade information is forbidden since it hides unfavorable legal consequences. MEMP is a new concept. This paper discusses it by putting forward a framework, which consists of four important procedures of design, reification, transformation and inference. The important features of MEMP are representation personalization and localization, accurate cross-domain message exchange, true result reasoning, context-based reification, and model-free template design and use. In future, a successful realization of MEMP in design will drastically change our existing e-trade modes, lift the quality of e-business, and lead to a more efficient emarketplace brought by higher accuracy of meaning understanding, broader scope of business interaction, and richer etrade functions. © 2010 IEEE.