A laboratory-scale anaerobic/anoxic/oxic (A²O) reactor followed by the microfiltration (MF) system was operated to evaluate the performance on the organics and nutrients removal from synthetic wastewater and the effluent reuse potential. The effects of different reactor hydraulic retention times (HRTs; 8, 10, and 12 hours), influent C/N ratios (5, 10, and 20), and influent C/P ratios (50, 80, and 200) were investigated. When the influent C/N ratio was at 10 or above and the C/P ratio was at around 200, the effluent quality for the reactor was excellent, meeting the discharge standard of China (1^st grade A), with the removal efficiency for chemical oxygen demand (COD), ammonia nitrogen (NH₃-N), total nitrogen (TN), and total phosphorus (TP) at 97%, 98%, 80%, and 78%, respectively. The MF membrane system showed an excellent performance on the further removal of suspended solids (SS) (to <1 mg/L) and turbidity (to <0.1 NTU). In addition, the final effluent/permeate showed a stable and excellent quality in terms of color, COD, and NH₃-N contents (3 PtCo, 10 mg/L, and 0.01 mg/L, respectively), good enough to meet the quality goals for regional reuse purposes.