Experimental investigation was conducted to characterize the responses of high performance concrete (HPC) subjected to multiaxial compressive stresses. The HPC specimens were prepared with three different mix proportions, which corresponds to three different uniaxial compressive strengths. The cubic specimens with size of 100 mm for each edge were tested with servo-hydraulic actuators at different stress ratios. The principal stresses and strains of the specimens were recorded, and the failure of the cubic specimens under various stress states was examined. The experimental results indicated that the stress states and stress ratios had significant influence on the strength and deformation of HPC under biaxial and triaxial compression, especially under triaxial compression. Failure criteria were proposed for the HPC specimens under biaxial and triaxial compressive loading. The test results provided a valuable reference for obtaining multi-axial constitutive law for HPC.