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Generation of tunable and pulsatile concentration gradients via microfluidic network
Zhou B.1; Xu W.2; Wang C.1; Chau Y.1; Zeng X.1; Zhang X.-X.2; Shen R.3; Wen W.1
2014
Source PublicationMicrofluidics and Nanofluidics
ISSN1613-4982
Volume18Issue:2Pages:175-184
Abstract

We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.

DOI10.1007/s10404-014-1432-9
URLView the original
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Instruments & Instrumentation ; Physics
WOS SubjectNanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Fluids & Plasmas
WOS IDWOS:000348978800003
Scopus ID2-s2.0-84922000426
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Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Hong Kong University of Science and Technology
2.King Abdullah University of Science and Technology
3.Institute of Physics Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhou B.,Xu W.,Wang C.,et al. Generation of tunable and pulsatile concentration gradients via microfluidic network[J]. Microfluidics and Nanofluidics, 2014, 18(2), 175-184.
APA Zhou B.., Xu W.., Wang C.., Chau Y.., Zeng X.., Zhang X.-X.., Shen R.., & Wen W. (2014). Generation of tunable and pulsatile concentration gradients via microfluidic network. Microfluidics and Nanofluidics, 18(2), 175-184.
MLA Zhou B.,et al."Generation of tunable and pulsatile concentration gradients via microfluidic network".Microfluidics and Nanofluidics 18.2(2014):175-184.
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