Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells

doi:10.1039/c6cc08109f

UM > Institute of Chinese Medical Sciences

Residential College	false
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	Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells
	Liu, Chenfu 1; Yang, Chao 2; Lu, Lihua 1,3; Wang, Wanhe 1; Tan, Weihong 4,5; Leung, Chung-Hang2 ; Ma, Dik-Lung 1
	2017-03-07
Source Publication	CHEMICAL COMMUNICATIONS
ISSN	1359-7345
Volume	53 Issue:19 Pages:2822-2825
Abstract	Two luminescent iridium(III) complexes, 1 and 2, were synthesized and evaluated for their ability to probe COX-2 in human cancer cells. This is the first application of iridium( III) complexes as imaging agents for COX-2. We demonstrate that complex 1 differentiates cancer cells from normal cells with high stability and low cytotoxicity.
DOI	10.1039/c6cc08109f
URL	View the original
Indexed By	SCIE ; IC
Language	英語English
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000396029600005
Publisher	ROYAL SOC CHEMISTRY
The Source to Article	WOS
Scopus ID	2-s2.0-85014307791
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Tan, Weihong; Leung, Chung-Hang; Ma, Dik-Lung
Affiliation	1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 3.College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China 4.Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, USA 5.Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha, China
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Liu, Chenfu,Yang, Chao,Lu, Lihua,et al. Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells[J]. CHEMICAL COMMUNICATIONS, 2017, 53(19), 2822-2825.
APA	Liu, Chenfu., Yang, Chao., Lu, Lihua., Wang, Wanhe., Tan, Weihong., Leung, Chung-Hang., & Ma, Dik-Lung (2017). Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells. CHEMICAL COMMUNICATIONS, 53(19), 2822-2825.
MLA	Liu, Chenfu,et al."Luminescent iridium(III) complexes as COX-2-specific imaging agents in cancer cells".CHEMICAL COMMUNICATIONS 53.19(2017):2822-2825.

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