The number of postgraduate students from Mainland China who study in foreign universities has increased signifi cantly in the past decade. Some of these Chinese postgraduate students opt to study in other Chinese countries and cities, like Macau, partly with the belief that doing so would require less cultural adjustment.Our chapter inquires into factors related to self-reported mental health in a sample of Mainland Chinese postgraduate students in Macau, and the results indicate that higher levels of acculturative stress (but not academic stress) are associated with poorer mental health-results that call attention to the need to conceptualize cultural experience and adjustment beyond notions of ethnicity and race. The results also show how psychological resilience is associated with better mental health. The results are discussed with references to the importance of culture in understanding Asian learners well-being.