| Residential College | false |
| Status | 已發表Published |
| A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease | |
Zhong, Hai-Jing1 ; Wang, Wanhe2; Kang, Tian-Shu1; Yan, Hui3; Yang, Yali3; Xu, Lipeng3; Wang, Yuqiang3; Ma, Dik-Lung2 ; Leung, Chung-Hang1
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| 2017-01-12 | |
| Source Publication | JOURNAL OF MEDICINAL CHEMISTRY
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| ISSN | 0022-2623 |
| Volume | 60Issue:1Pages:497-503 |
| Abstract | We report herein the identification of the rhodium(III) complex [Rh(phq)(2)(MOPIP)](+) (1): as a potent and selective ATP-competitive neural precursor cell expressed developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure-activity relationship analysis indicated that the overall organometallic design of complex 1 was important for anti-inflammatory, activity. Complex 1 showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease. |
| DOI | 10.1021/acs.jmedchem.6b00250 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000392035100034 |
| Publisher | AMER CHEMICAL SOC |
| The Source to Article | WOS |
| Scopus ID | 2-s2.0-85018193114 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Ma, Dik-Lung; Leung, Chung-Hang |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao P. R China 2.Department of Chemistry, Hong Kong Baptist University, T1303, Cha Chi-Ming Science Tower, Kowloon Tong, Hong Kong, P. R. China 3.Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Zhong, Hai-Jing,Wang, Wanhe,Kang, Tian-Shu,et al. A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60(1), 497-503. |
| APA | Zhong, Hai-Jing., Wang, Wanhe., Kang, Tian-Shu., Yan, Hui., Yang, Yali., Xu, Lipeng., Wang, Yuqiang., Ma, Dik-Lung., & Leung, Chung-Hang (2017). A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease. JOURNAL OF MEDICINAL CHEMISTRY, 60(1), 497-503. |
| MLA | Zhong, Hai-Jing,et al."A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease".JOURNAL OF MEDICINAL CHEMISTRY 60.1(2017):497-503. |
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