The present study investigated the subjective well-being of Macao people. Life domains like salary, family relation and health, as well as income social comparison, were used to predict the two indicators of subjective well-being: life satisfaction and happiness. A random sample of 2,060 people was interviewed at home in person in a large scale survey commissioned by the government. Results indicated life domains like finance, family relations, mental health, housing conditions, leisure activities and relations with spouse / partner contributed to life satisfaction and happiness, and income social comparison could predict life satisfaction. Though it is suggested that socio-demographic factors may not be potent predictor variables (e.g., Myers & Diener, 1995), the present investigation suggested that age, education level, and being an immigrant significantly influenced life satisfaction and happiness.