A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters

doi:10.1039/c6qm00068a

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters
	Wang, MD 1; Wang, WH 1; Liu, CF 1; Liu, JB 1; Kang, TS2 ; Leung, CH2 ; Ma, DL 1
	2017
Source Publication	MATERIALS CHEMISTRY FRONTIERS
ISSN	2052-1537
Volume	1 Issue:1 Pages:128-131
Abstract	A switch-on gene deletion detection platform is reported based on the alteration of the effective distance between G-quadruplex DNA and silver nanoclusters (AgNCs). Moreover, the role of the G- quadruplex structure in interacting with AgNCs has also been demonstrated. The detection of the deletion mutants of LMP1 and CCR5 genes is performed as the proof-of-concept of our assay. Finally, the potential biological application of the assay was demonstrated in 10% v/v human serum.
DOI	10.1039/c6qm00068a
Indexed By	SCIE
Language	英語English
WOS Research Area	Chemistry ; Materials Science
WOS Subject	Chemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS ID	WOS:000412438100012
Scopus ID	2-s2.0-85042087867
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Ma, DL
Affiliation	1.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China 2.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation GB/T 7714	Wang, MD,Wang, WH,Liu, CF,et al. A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters[J]. MATERIALS CHEMISTRY FRONTIERS, 2017, 1(1), 128-131.
APA	Wang, MD., Wang, WH., Liu, CF., Liu, JB., Kang, TS., Leung, CH., & Ma, DL (2017). A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters. MATERIALS CHEMISTRY FRONTIERS, 1(1), 128-131.
MLA	Wang, MD,et al."A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters".MATERIALS CHEMISTRY FRONTIERS 1.1(2017):128-131.

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