Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities

doi:10.3390/molecules24132495

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	Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
	Maram Hussein Zahra 1; Tarek A.R. Salem 2,3; Bishoy El-Aarag 1,4; Nermeen Yosri 5; Samah EL-Ghlban 4; Kholoud Zaki 5; Amel H. Marei 5; Aida Abd El-Wahed 5,6,7; Aamer Saeed 8; Alfi Khatib 9; Mohamed F. AlAjmi 10; Abdulrahman M. Shathili 11; Jianbo Xiao 12; Shaden A. M. Khalifa 13,14; Hesham R. El-Seedi 5,6,11,15
	2019-07
Source Publication	MOLECULES
ISSN	1420-3049
Volume	24 Issue:13
Abstract	BACKGROUND/AIM: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers. METHODS: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model. RESULTS: A. zerumbet extracts, specially CH₂Cl₂ and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH₂Cl₂ extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, ¹H-NMR and ¹³C-NMR. A. zerumbet extracts, specially MeOH and CH₂Cl₂ extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC₅₀ values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively. CONCLUSION: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
Keyword	5,6-dehydrokawain Alpinia Zerumbet Ehrlich Ascites Carcinoma Anti-oxidant Anti-tumor
DOI	10.3390/molecules24132495
Indexed By	SCIE
Language	英語English
WOS Research Area	Biochemistry & Molecular Biology ; Chemistry
WOS Subject	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS ID	WOS:000476700300149
Scopus ID	2-s2.0-85068848824
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology,Okayama University, Okayama 7008530, Japan 2.Department of Biochemistry, College of Medicine, Qassim University, Al-Qassim 51452, Saudi Arabia 3.Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City,Sadat City 32958, Egypt 4.Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University,Shebin El-Koom 32512, Egypt 5.Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom 32512, Egypt 6.Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre,Box 574, SE-751 23 Uppsala, Sweden 7.Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre,Giza 12627, Egypt 8.Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan 9.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia,Kuantan 25200, Pahang, Malaysia 10.Pharmacognosy Group, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia 11.Al-Rayan Research and Innovation Center, Al-Rayan Colleges, Medina 42541, Saudi Arabia 12.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China 13.Clinical Research Centre, Karolinska University Hospital, 14186 Huddinge, Sweden 14.Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University,SE 106 91 Stockholm, Sweden 15.College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Recommended Citation GB/T 7714	Maram Hussein Zahra,Tarek A.R. Salem,Bishoy El-Aarag,et al. Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities[J]. MOLECULES, 2019, 24(13).
APA	Maram Hussein Zahra., Tarek A.R. Salem., Bishoy El-Aarag., Nermeen Yosri., Samah EL-Ghlban., Kholoud Zaki., Amel H. Marei., Aida Abd El-Wahed., Aamer Saeed., Alfi Khatib., Mohamed F. AlAjmi., Abdulrahman M. Shathili., Jianbo Xiao., Shaden A. M. Khalifa., & Hesham R. El-Seedi (2019). Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities. MOLECULES, 24(13).
MLA	Maram Hussein Zahra,et al."Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities".MOLECULES 24.13(2019).

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