The previous literature has examined leisure satisfaction and quality of life but majority of studies were conducted in Western countries. Policy makers worldwide have struggled to balance residents’ leisure satisfaction and tourism development. This study is conducted in Macao, China, a fast-growing tourism destination in Asia. Results indicated that local residents’ leisure satisfaction is positively related to their perceived quality of life while local residents’ perceived quality of life is positively associated with their evaluation of the perceived benefits of tourism. The results generated from that evaluation positively lead to residents’ support of tourism development. Results indicated that it is worthwhile for the policy makers to invest resources in local residents’ leisure satisfaction and quality of life since this will eventually help to support tourism development. The results of this study provide significant implications for policy makers.