The interaction of tolerogenic CD103 dendritic cells (DCs) with regulatory T (Tregs) cells modulates immune responses by inducing immune tolerance. Hence, we determined the proportion of these cells in the peripheral blood mononuclear cells (PBMC) of asthmatic patients. We observed lower trends of CD11bCD103 DCs and CD86 within CD11bCD103 DCs, while increased levels of Foxp3 expressing CD25TNFR2 cells in asthmatics. There was a positive correlation in the expression of Foxp3 within CD3CD4CD25TNFR2 Tregs and CD11bCD103 as well as the expression of CD86 within HLA-DRCD11cCD11bCD103 DCs. In conclusion, we suggest that the increased levels of Tregs in blood could continuously suppress the T helper 2 (Th2) cells activation in the circulation which is also supported by the increase of anti-inflammatory cytokines IL-10 and TNF. Overall, functional immunoregulation of the regulatory cells, particularly Tregs, exhibit immune suppression and induce immune tolerance linked with the immune activation by the antigen presenting cells (APC).