A mitochondria-targeting NIR fluorescent potassium ion sensor: Real-time investigation of the mitochondrial K+regulation of apoptosisin situ

doi:10.1039/d0cc00579g

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	A mitochondria-targeting NIR fluorescent potassium ion sensor: Real-time investigation of the mitochondrial K+regulation of apoptosisin situ
	Song,Guangjie1,2 ; Jiang,Di2 ; Wang,Lei 1; Ning,Juewei 1; Sun,Xiangzhong 1; Su,Fengyu 3; Chen,Meiwan2 ; Tian,Yanqing 1
	2020-05-18
Source Publication	Chemical Communications
ISSN	1359-7345
Volume	56 Issue:40 Pages:5405-5408
Other Abstract	The first NIR fluorescent mitochondria-targeting Ksensor, denoted asTAC-Rh, was developed. The produced sensor consists of a rhodamine analog as the fluorophore and triazacryptand (TAC) as the Krecognition unit. Compared to the Ksensors reported previously,TAC-Rhexhibits two unique optical properties: the largest Stokes shifts (120 nm) and the longest emission peak wavelength (720 nm). With the assistance of this novel sensor, real-time changes of Kconcentrations in mitochondria during apoptosis were monitored for the first time. Moreover, it was also the first time that the relationship between mitochondrial Kflux and apoptosis was investigated in real time using fluorescence imaging.
DOI	10.1039/d0cc00579g
URL	View the original
Indexed By	SCIE ; IC
Language	英語English
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000536772700013
Publisher	ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Scopus ID	2-s2.0-85084940205
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Su,Fengyu; Chen,Meiwan; Tian,Yanqing
Affiliation	1.Department of Materials Science and Engineering Southern University of Science and Technology, Shenzhen, 518055, China 2.State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China 3.Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology, Shenzhen, 518055, China
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Song,Guangjie,Jiang,Di,Wang,Lei,et al. A mitochondria-targeting NIR fluorescent potassium ion sensor: Real-time investigation of the mitochondrial K+regulation of apoptosisin situ[J]. Chemical Communications, 2020, 56(40), 5405-5408.
APA	Song,Guangjie., Jiang,Di., Wang,Lei., Ning,Juewei., Sun,Xiangzhong., Su,Fengyu., Chen,Meiwan., & Tian,Yanqing (2020). A mitochondria-targeting NIR fluorescent potassium ion sensor: Real-time investigation of the mitochondrial K+regulation of apoptosisin situ. Chemical Communications, 56(40), 5405-5408.
MLA	Song,Guangjie,et al."A mitochondria-targeting NIR fluorescent potassium ion sensor: Real-time investigation of the mitochondrial K+regulation of apoptosisin situ".Chemical Communications 56.40(2020):5405-5408.

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