A metal-based inhibitor of tumor necrosis factor-α

doi:10.1002/anie.201202937

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	A metal-based inhibitor of tumor necrosis factor-α
	Leung C.-H.1,2 ; Zhong H.-J.1,2 ; Yang H.3; Cheng Z.3; Chan D.S.-H.3; Ma V.P.-Y.3; Abagyan R.4; Wong C.-Y.5; Ma D.-L.3
	2012
Source Publication	Angewandte Chemie - International Edition
ISSN	14337851
Volume	51 Issue:36 Pages:9010
Abstract	Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keyword	Inhibitors Iridium(Iii) Complexes Metal-based Inhibitors Protein-protein Interactions Tumor Necrosis Factor
DOI	10.1002/anie.201202937
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000308043900008
The Source to Article	Scopus
Scopus ID	2-s2.0-84865859280
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Univ Macau, Inst Chinese Med Sci, Macao, Peoples R China 2.Univ Macau, State Key Lab Qual Res Chinese Med, Macao, Peoples R China 3.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China 4.Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA 5.City Univ Hong Kong, Dept Biol & Chem, Kowloon Tong, Hong Kong, Peoples R China
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Leung C.-H.,Zhong H.-J.,Yang H.,et al. A metal-based inhibitor of tumor necrosis factor-α[J]. Angewandte Chemie - International Edition, 2012, 51(36), 9010.
APA	Leung C.-H.., Zhong H.-J.., Yang H.., Cheng Z.., Chan D.S.-H.., Ma V.P.-Y.., Abagyan R.., Wong C.-Y.., & Ma D.-L. (2012). A metal-based inhibitor of tumor necrosis factor-α. Angewandte Chemie - International Edition, 51(36), 9010.
MLA	Leung C.-H.,et al."A metal-based inhibitor of tumor necrosis factor-α".Angewandte Chemie - International Edition 51.36(2012):9010.

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