| Residential College | false |
| Status | 已發表Published |
| Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer | |
Xie,Qinghua1; Li,Xia2; Wang,Guanquan3; Hou,Xuan1; Wang,Yujun4; Yu,Hongbo4; Qu,Changfa4; Luo,Shunzhong3; Cui,Yali4; Xia,Chuanqin1 ; Wang,Ruibing5
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| 2017-03-01 | |
| Source Publication | Journal of Radioanalytical and Nuclear Chemistry
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| ISSN | 0236-5731 |
| Volume | 311Issue:3Pages:1697-1708 |
| Abstract | Here we reported the radiolabeling and evaluation of a novel I-radiolabeled quercetin for the treatment of dedifferentiated thyroid cancers. The human thyroid cancer cell lines (FTC-133, TT and DRO) experienced much higher uptake of I-quercetin as compared to the free I. And the proliferation inhibition rate of I-quercetin on in vitro DRO cell line was 86.87 ± 7.15%. Biodistribution and SPECT analysis demonstrated that the injected radioactivity mainly accumulated in tumors. The tumor volume in the treatment group was dramatically inhibited in comparison with the control group. |
| Keyword | 131i-quercetin Biodistribution Dedifferentiated Thyroid Cancer Proliferation Inhibition Radiopharmaceutical |
| DOI | 10.1007/s10967-016-5143-4 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Chemistry ; Nuclear Science & Technology |
| WOS Subject | Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology |
| WOS ID | WOS:000398027800017 |
| Scopus ID | 2-s2.0-85007190531 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
| Corresponding Author | Xia,Chuanqin |
| Affiliation | 1.College of Chemistry,Sichuan University,Chengdu,China 2.College of Mathematics,Sichuan University,Chengdu,China 3.Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang,China 4.Department of Nuclear Medicine,Harbin Medical University Cancer Hospital,Harbin,China 5.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao |
| Recommended Citation GB/T 7714 | Xie,Qinghua,Li,Xia,Wang,Guanquan,et al. Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer[J]. Journal of Radioanalytical and Nuclear Chemistry, 2017, 311(3), 1697-1708. |
| APA | Xie,Qinghua., Li,Xia., Wang,Guanquan., Hou,Xuan., Wang,Yujun., Yu,Hongbo., Qu,Changfa., Luo,Shunzhong., Cui,Yali., Xia,Chuanqin., & Wang,Ruibing (2017). Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer. Journal of Radioanalytical and Nuclear Chemistry, 311(3), 1697-1708. |
| MLA | Xie,Qinghua,et al."Preparation and evaluation of 131I-quercetin as a novel radiotherapy agent against dedifferentiated thyroid cancer".Journal of Radioanalytical and Nuclear Chemistry 311.3(2017):1697-1708. |
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