C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells

doi:10.1016/j.steroids.2015.12.008

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells
	Yin,Zhi Qi 1; Yu,Shu Le 1,2; Wei,Yu Jian 3; Ma,Lin 1,2; Wu,Zheng Feng 1,2; Wang,Lei 4; Zhang,Qing Wen5 ; Zhao,Ming 6; Ye,Wen Cai 4; Che,Chun Tao 6; Zhang,Jian 2
	2016-02
Source Publication	Steroids
ISSN	0039-128X
Volume	106 Pages:55-61
Abstract	Two new (1–2) and three known (3–5) C steroidal glycosides were isolated from Cynanchum stauntonii. Their structures were elucidated on the basis of 1D and 2D-NMR spectroscopic data as well as HRTOFMS analysis. The cytotoxicity of the compounds against A549, HepG2, and 4T1 cell lines were evaluated by MTT assay. Compound 4 exhibited good inhibitory activities with the IC values 26.82, 12.24, and 44.12 μM, respectively. Furthermore, compound 4 could induce G1 phase arrest, upregulate the expression levels of caspases-3, -9, and Bax, and downregulate the expression level of Bcl-2. These results indicated that compound 4 might be valuable to anticancer drug candidates.
Keyword	Apoptosis C21 Steroidal Glycoside Caspase Cynanchum Stauntonii
DOI	10.1016/j.steroids.2015.12.008
URL	View the original
Indexed By	SCIE ; IC
Language	英語English
WOS Research Area	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS Subject	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS ID	WOS:000371191000007
Scopus ID	2-s2.0-84990051375
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Yin,Zhi Qi; Zhang,Jian
Affiliation	1.Department of Natural Medicinal Chemistry & State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing,210009,China 2.Laboratory of Translational Medicine,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing,210028,China 3.The First Clinical Medical Institute,Nanjing Medical University,Nanjing,210000,China 4.Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research,Jinan University,Guangzhou,510632,China 5.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences,University of Macau,Macao SAR,China 6.Department of Medicinal Chemistry and Pharmacognosy,and WHO Collaborating Center for Tradition Medicine,College of Pharmacy,University of Illinois at Chicago,Chicago,60612,United States
Recommended Citation GB/T 7714	Yin,Zhi Qi,Yu,Shu Le,Wei,Yu Jian,et al. C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells[J]. Steroids, 2016, 106, 55-61.
APA	Yin,Zhi Qi., Yu,Shu Le., Wei,Yu Jian., Ma,Lin., Wu,Zheng Feng., Wang,Lei., Zhang,Qing Wen., Zhao,Ming., Ye,Wen Cai., Che,Chun Tao., & Zhang,Jian (2016). C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells. Steroids, 106, 55-61.
MLA	Yin,Zhi Qi,et al."C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells".Steroids 106(2016):55-61.

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