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Status | 已發表Published |
The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein | |
Scheib,Holger1; Nekaris,K. Anne Isola2,3; Rode-Margono,Johanna2,4; Ragnarsson,Lotten5; Baumann,Kate1; Dobson,James S.1; Wirdateti,Wirdateti6; Nouwens,Amanda7; Nijman,Vincent2,3; Martelli,Paolo8; Ma,Rui9![]() ![]() ![]() ![]() | |
2020-01-28 | |
Source Publication | Toxins
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ISSN | 2072-6651 |
Volume | 12Issue:2Pages:86 |
Abstract | Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals. |
Keyword | Allergen Dander Evolution Primate Venom |
DOI | 10.3390/toxins12020086 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Food Science & Technology ; Toxicology |
WOS Subject | Food Science & Technology ; Toxicology |
WOS ID | WOS:000519117300053 |
Publisher | MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
Scopus ID | 2-s2.0-85078831206 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Translational Medicine Faculty of Health Sciences |
Corresponding Author | Kwok,Hang Fai; Fry,Bryan Grieg |
Affiliation | 1.Venom Evolution Lab: School of Biological Sciences,University of Queensland,St Lucia,4072,Australia 2.Nocturnal Primate Research Group,Department of Social Sciences,Oxford Brookes University,Oxford,OX3 0BP,United Kingdom 3.Centre for Functional Genomics,Department of Health and Life Sciences,Oxford Brookes University,Oxford,OX3 0BP,United Kingdom 4.North of England Zoological Society/Chester Zoo,Chester,CH2 1LH,United Kingdom 5.Institute for Molecular Biosciences,University of Queensland,St Lucia,4072,Australia 6.Research Center for Biology-LIPI,Jakarta-Bogor, Cibinong,16911,Indonesia 7.School of Chemistry and Molecular Biosciences,University of Queensland,St Lucia,4072,Australia 8.Veterinary Department: Ocean Park,Hong Kong,Hong Kong 9.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Taipa,Avenida de Universidade,Macao |
Corresponding Author Affilication | Faculty of Health Sciences |
Recommended Citation GB/T 7714 | Scheib,Holger,Nekaris,K. Anne Isola,Rode-Margono,Johanna,et al. The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein[J]. Toxins, 2020, 12(2), 86. |
APA | Scheib,Holger., Nekaris,K. Anne Isola., Rode-Margono,Johanna., Ragnarsson,Lotten., Baumann,Kate., Dobson,James S.., Wirdateti,Wirdateti., Nouwens,Amanda., Nijman,Vincent., Martelli,Paolo., Ma,Rui., Lewis,Richard J.., Kwok,Hang Fai., & Fry,Bryan Grieg (2020). The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein. Toxins, 12(2), 86. |
MLA | Scheib,Holger,et al."The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein".Toxins 12.2(2020):86. |
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