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The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein
Scheib,Holger1; Nekaris,K. Anne Isola2,3; Rode-Margono,Johanna2,4; Ragnarsson,Lotten5; Baumann,Kate1; Dobson,James S.1; Wirdateti,Wirdateti6; Nouwens,Amanda7; Nijman,Vincent2,3; Martelli,Paolo8; Ma,Rui9; Lewis,Richard J.5; Kwok,Hang Fai9; Fry,Bryan Grieg1
2020-01-28
Source PublicationToxins
ISSN2072-6651
Volume12Issue:2Pages:86
Abstract

Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals.

KeywordAllergen Dander Evolution Primate Venom
DOI10.3390/toxins12020086
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000519117300053
PublisherMDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Scopus ID2-s2.0-85078831206
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Translational Medicine
Faculty of Health Sciences
Corresponding AuthorKwok,Hang Fai; Fry,Bryan Grieg
Affiliation1.Venom Evolution Lab: School of Biological Sciences,University of Queensland,St Lucia,4072,Australia
2.Nocturnal Primate Research Group,Department of Social Sciences,Oxford Brookes University,Oxford,OX3 0BP,United Kingdom
3.Centre for Functional Genomics,Department of Health and Life Sciences,Oxford Brookes University,Oxford,OX3 0BP,United Kingdom
4.North of England Zoological Society/Chester Zoo,Chester,CH2 1LH,United Kingdom
5.Institute for Molecular Biosciences,University of Queensland,St Lucia,4072,Australia
6.Research Center for Biology-LIPI,Jakarta-Bogor, Cibinong,16911,Indonesia
7.School of Chemistry and Molecular Biosciences,University of Queensland,St Lucia,4072,Australia
8.Veterinary Department: Ocean Park,Hong Kong,Hong Kong
9.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Taipa,Avenida de Universidade,Macao
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Scheib,Holger,Nekaris,K. Anne Isola,Rode-Margono,Johanna,et al. The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein[J]. Toxins, 2020, 12(2), 86.
APA Scheib,Holger., Nekaris,K. Anne Isola., Rode-Margono,Johanna., Ragnarsson,Lotten., Baumann,Kate., Dobson,James S.., Wirdateti,Wirdateti., Nouwens,Amanda., Nijman,Vincent., Martelli,Paolo., Ma,Rui., Lewis,Richard J.., Kwok,Hang Fai., & Fry,Bryan Grieg (2020). The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein. Toxins, 12(2), 86.
MLA Scheib,Holger,et al."The toxicological intersection between allergen and toxin: A structural comparison of the cat dander allergenic protein fel d1 and the slow loris brachial gland secretion protein".Toxins 12.2(2020):86.
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