| Residential College | false |
| Status | 已發表Published |
| In vitro anti-influenza viral activities of constituents from Caesalpinia sappan | |
Ai-Lin Liu1; Shi-Hui Shu1; Hai-Lin Qin1; Simon Ming Yuen Lee2  ; Yi-Tao Wang2; Guan-Hua Du1
| |
| 2009 | |
| Source Publication | Planta Medica
 |
| ISSN | 320943 |
| Volume | 75Issue:4Pages:337 |
| Abstract | Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 μg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 μg/mL, respectively. © Georg Thieme Verlag KG Stuttgart. |
| Keyword | Caesalpinia Sappan Influenza Virus Leguminosae Neuraminidase Sappanchalcone |
| DOI | 10.1055/s-0028-1112208 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| WOS ID | WOS:000264895100011 |
| The Source to Article | Scopus |
| Scopus ID | 2-s2.0-65649134653 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES Institute of Chinese Medical Sciences |
| Corresponding Author | Simon Ming Yuen Lee |
| Affiliation | 1.Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China 2.Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Ai-Lin Liu,Shi-Hui Shu,Hai-Lin Qin,et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan[J]. Planta Medica, 2009, 75(4), 337. |
| APA | Ai-Lin Liu., Shi-Hui Shu., Hai-Lin Qin., Simon Ming Yuen Lee., Yi-Tao Wang., & Guan-Hua Du (2009). In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Medica, 75(4), 337. |
| MLA | Ai-Lin Liu,et al."In vitro anti-influenza viral activities of constituents from Caesalpinia sappan".Planta Medica 75.4(2009):337. |
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