Intra-body communication (IBC) uses the human body as the transmission medium for electrical signals, and it features the following advantages: low power consumption, strong anti-interference ability, high data security, and broad application scenarios. However, some technical issues still need to be addresses, such as the choice of the best modulation and demodulation scheme in different application scenarios, influence of human activity on IBC performance, variable signal-to-noise ratio (SNR), and influence of transmission distance change on different modulation and demodulation methods. This paper adopts direct sequence spread spectrum (DSSS) communication and phase modulation to realize DSSS-differential phase shift keying (DPSK) and DPSK modulation transmission of baseband data. Moreover, the Costas loop method is employed to achieve reliable symbol recovery. Under the same conditions, in vivo experiments were conducted to compare the performance of DSSS-DPSK and DPSK galvanic coupling IBC transceivers. Notably, these transceivers are affected by the changes in SNR, transmission distance, and human activities. Results show that the bit error rate (BER) of the DPSK scheme is 40 times larger than the DSSS-DPSK scheme in a 30 cm channel length and different SNR experiments. When the BER performance changes from extremely poor (1.40× 10) to excellent (1.51×10), the SNR of DSSS-DPSK scheme only needs to be improved by 16 dB. In contrast, when the BER performance changes from extremely poor (1.54× 10) to good (1.65× 10), the SNR of DPSK scheme needs to be improved by 25 dB. With a SNR of -5 dB, the BER ratios of the DPSK scheme is 7 times larger than the DSSS-DPSK scheme. Also, DSSS-DPSK scheme is more sensitive to changes in motion status than DPSK.