Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root

doi:10.1016/j.carbpol.2015.05.059

UM > Institute of Chinese Medical Sciences

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	Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root
	Jia X.1 ; Zhang C.1 ; Qiu J.1 ; Wang L.2; Bao J.1 ; Wang K.1 ; Zhang Y.1 ; Chen M.1 ; Wan J.1 ; Su H.1 ; Han J.2; He C.1
	2015
Source Publication	Carbohydrate Polymers
ISSN	1448617
Volume	132 Pages:67
Abstract	Three novel acidic polysaccharides termed PRM1, PRM3 and PRM5 were purified from Rhynchosia minima root using DEAE-52 cellulose and sephadex G-150 column chromatography. Their structures were characterized by ultraviolet (UV) and Fourier transform infrared (FTIR) spectrometry, gel permeation chromatography (GPC), gas chromatography-mass spectrometry (GC-MS), and differential scanning colorimeter (DSC) analysis. The uronic acid contents of PRM1, PRM3 and PRM5 were 30.7%, 12.7% and 47.7%, respectively. PRM1 (143.2 kDa), PRM3 (105.3 kDa) and PRM5 (162.1 kDa) were heteropolysaccharides because they were composed of arabinose, mannose, glucose and galactose. Their enthalpy values were 201.0, 111.0 and 206.8 J/g, respectively. PRM3 and PRM1 exhibited strong in vitro anticancer activity against lung cancer A549 and liver cancer HepG2 cells in a dose-dependent manner. These findings suggested that PRM1 and PRM3 could be potentially developed as natural anticancer agents. © 2015 Elsevier Ltd. All rights reserved.
Keyword	Anticancer Polysaccharide Purification Rhynchosia Minima
DOI	10.1016/j.carbpol.2015.05.059
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Chemistry ; Polymer Science
WOS Subject	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS ID	WOS:000361184900009
The Source to Article	Scopus
Scopus ID	2-s2.0-84934275288
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	He C.
Affiliation	1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China 2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Jia X.,Zhang C.,Qiu J.,et al. Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root[J]. Carbohydrate Polymers, 2015, 132, 67.
APA	Jia X.., Zhang C.., Qiu J.., Wang L.., Bao J.., Wang K.., Zhang Y.., Chen M.., Wan J.., Su H.., Han J.., & He C. (2015). Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root. Carbohydrate Polymers, 132, 67.
MLA	Jia X.,et al."Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root".Carbohydrate Polymers 132(2015):67.

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