Discovery of a VHL and HIF1α interaction inhibitor with: In vivo angiogenic activity via structure-based virtual screening

doi:10.1039/c6cc04938a

UM > Faculty of Health Sciences > DEPARTMENT OF PHARMACEUTICAL SCIENCES

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	Discovery of a VHL and HIF1α interaction inhibitor with: In vivo angiogenic activity via structure-based virtual screening
	Chao Yang 1; Wanhe Wang 2; Linmin Chen 1; Jiaxin Liang 1; Sheng Lin 2; Ming-Yuen Lee1 ; Dik-Lung Ma 2; Chung-Hang Leung1
	2016
Source Publication	Chemical Communications
ISSN	13597345
Volume	52 Issue:87 Pages:12837
Abstract	We describe herein compound 1, which is similar to many known natural products, as an inhibitor of the VHL-HIF1α interaction via structure-based virtual screening. Compound 1 disrupts VHL-mediated HIF1α degradation, leading to significantly increased VEGF expression. To our knowledge, compound 1 is a member of only the second class of small molecule inhibitors of the VHL-HIF1α interaction. © The Royal Society of Chemistry 2016.
DOI	10.1039/c6cc04938a
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000387025600010
The Source to Article	Scopus
Scopus ID	2-s2.0-84992695221
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding Author	Dik-Lung Ma; Chung-Hang Leung
Affiliation	1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Chao Yang,Wanhe Wang,Linmin Chen,et al. Discovery of a VHL and HIF1α interaction inhibitor with: In vivo angiogenic activity via structure-based virtual screening[J]. Chemical Communications, 2016, 52(87), 12837.
APA	Chao Yang., Wanhe Wang., Linmin Chen., Jiaxin Liang., Sheng Lin., Ming-Yuen Lee., Dik-Lung Ma., & Chung-Hang Leung (2016). Discovery of a VHL and HIF1α interaction inhibitor with: In vivo angiogenic activity via structure-based virtual screening. Chemical Communications, 52(87), 12837.
MLA	Chao Yang,et al."Discovery of a VHL and HIF1α interaction inhibitor with: In vivo angiogenic activity via structure-based virtual screening".Chemical Communications 52.87(2016):12837.

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