With the recent development of stains simulation on warp-weft style fabric materials, high realistic visual effects of real-life stains can be plausibly simulated effectively. However, the previous method relies on the limited single solvent dyeing assumption, while in the real world, the fabric is often contaminated by different stains simultaneously. To tackle the multi-stains simulation problem, we propose a novel duel-stage solvents computational model (DSSM-TLM), which essentially extended the triple-layer model (TLM) (Zheng et al. in IEEE Trans Vis Comput Graph 25(7):2471–2481, 2019. https://doi.org/10.1109/TVCG.2018.2832039) into a more general version. We demonstrated that various effects, such as oil-water stain mixing or alcohol-water stain mixing, can be simulated correctly first ever. Moreover, the simulation process of our algorithm is consistent with the real multi-solvent liquid diffusion process on a real fabric surface.