| Residential College | false |
| Status | 已發表Published |
| New enantiomeric isoquinoline alkaloids from Coptis chinensis | |
Wang L.1,2; Zhang S.-Y.1; Chen L.1; Huang X.-J.1,2; Zhang Q.-W.3  ; Jiang R.-W.1; Yao F.4; Ye W.-C.1,2
| |
| 2014-02 | |
| Source Publication | Phytochemistry Letters
 |
| ISSN | 1874-3900 |
| Volume | 7Issue:1Pages:89 |
| Abstract | A pair of new enantiomeric isoquinoline alkaloids, (+)- and (-)-5-hydroxyl-8-oxyberberine (1), along with nine known analogs (2-10) were isolated from the rhizoma of Coptis chinensis. Their structures with absolute configurations were elucidated on the basis of spectroscopic methods, X-ray diffraction analysis, and quantum chemical calculation. The antibacterial activities of 1-10 were also evaluated. Berberine (8) displayed synergism against methicillin-resistant Staphylococcus aureus (MRSA) in combination with ceftazidime and cefepiem. |
| Keyword | Coptis Chinensis Isoquinoline Alkaloid Ranunculaceae |
| DOI | 10.1016/j.phytol.2013.10.007 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Plant Sciences ; Pharmacology & Pharmacy |
| WOS Subject | Plant Sciences ; Chemistry, Medicinal |
| WOS ID | WOS:000330578100018 |
| The Source to Article | Scopus |
| Scopus ID | 2-s2.0-84887289858 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Zhang Q.-W.; Yao F.; Ye W.-C. |
| Affiliation | 1.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China 2.JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Jinan University, Guangzhou 510632, PR China 3.Institute of Chinese Medical Sciences, University of Macau, Macau, PR China 4.Department of Pharmacology, Medical College, Shantou University, Shantou 515041, PR China |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Wang L.,Zhang S.-Y.,Chen L.,et al. New enantiomeric isoquinoline alkaloids from Coptis chinensis[J]. Phytochemistry Letters, 2014, 7(1), 89. |
| APA | Wang L.., Zhang S.-Y.., Chen L.., Huang X.-J.., Zhang Q.-W.., Jiang R.-W.., Yao F.., & Ye W.-C. (2014). New enantiomeric isoquinoline alkaloids from Coptis chinensis. Phytochemistry Letters, 7(1), 89. |
| MLA | Wang L.,et al."New enantiomeric isoquinoline alkaloids from Coptis chinensis".Phytochemistry Letters 7.1(2014):89. |
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