A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression

doi:10.2174/0929867311320040009

UM > Institute of Chinese Medical Sciences

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	A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression
	Yang H.1; Ma V.P.-Y.1; Chan D.S.-H.1; He H.-Z.1; Leung C.-H.2 ; Ma D.-L.1
	2013
Source Publication	Current Medicinal Chemistry
ISSN	0929-8673
Volume	20 Issue:4 Pages:576-582
Abstract	A new cyclometallated iridium(III) complex with the 2,2'-biquinoline N-donor ligand has been synthesized and characterized. The interaction and affinity of the complex towards c-myc G-quadruplex and duplex DNA have been investigated using UV/Vis spectroscopy and gel mobility shift assay. These studies revealed that complex 1 binds to c-myc G-quadruplexes (Pu22 and Pu27) with high affinity but does not interact with duplex DNA either by intercalation or groove binding. The ability of 1 to stabilize c-myc G-quadruplex DNA in vitro has also been examined through a PCR stop assay and a cell-based luciferase reporter assay. Complex 1 displays promising cytotoxic activity against the HeLa cell line with sub-micromolar potency.
Keyword	C-myc Dna G-quadruplex Iridium(Iii) Metal Complex Oncogene Promoter Cyclometallated Iridium(Iii) Complex 2 2'-biquinoline N-donor
DOI	10.2174/0929867311320040009
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS Subject	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS ID	WOS:000316608900009
Publisher	BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES
The Source to Article	Scopus
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Ma D.-L.
Affiliation	1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation GB/T 7714	Yang H.,Ma V.P.-Y.,Chan D.S.-H.,et al. A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression[J]. Current Medicinal Chemistry, 2013, 20(4), 576-582.
APA	Yang H.., Ma V.P.-Y.., Chan D.S.-H.., He H.-Z.., Leung C.-H.., & Ma D.-L. (2013). A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression. Current Medicinal Chemistry, 20(4), 576-582.
MLA	Yang H.,et al."A cyclometallated iridium(III) complex as a c-myc G-Quadruplex stabilizer and down-regulator of c-myc oncogene expression".Current Medicinal Chemistry 20.4(2013):576-582.

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