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Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy
Dayong Wang1,2; Xiangqing Hou2,3; Xianghua Yu1; Tao Wang2,4; Zhenmiao Ye1; Jushuang Li2,4; Feifei Su5; Chengnan Guo2,4; Fang Peng2,4; Shuzhen Zhao2,4; Huihui Li2,4; Jingjing Zuo6; Dehua Su1; Lina Zhao1; Hemei Zhang1; Xiangyang Chen1; Ruoqiu Chen1; Qipeng Xie7; Chao Zheng8; Guangyun Mao2,4,6
2021-05-07
Source PublicationAging
ISSN1945-4589
Volume13Issue:9Pages:13061-13072
Abstract

Background: Previous studies concerning the effect of plasma hemoglobin (HB) and other factors that may modify the risk of death in people living with HIV/AIDS (PLHIV) treated with antiretroviral therapy (ART) are limited. Results: Higher HB was independently linked to a lower death risk in PLHIV, with a decrease of 29% (13%, 43%) per standard deviation (SD) increment after adjusting for CD4, VL and other potential factors [hazard ratio (HR): 0.71, 95% confidence interval (CI): 0.57-0.87, P<0.001]. In addition, the addition of HB to the predictive model containing VL and CD4 significantly improved the C-index, by 0.69% (95% CI: 0.68%–0.71%), and net discrimination, by 0.5% (95% CI: 0.0%–1.6%, P=0.040), when predicting the death risk of PLHIV. Conclusions: A lower level of HB was an independent risk factor for HIV/AIDS-associated death in PLHIV. HB combined with VL and CD4 may be an appropriate predictive model of the death risk of PLHIV. Materials and methods: A propensity-score matching (PSM) approach was applied to select a total of 750 PLHIV (150 deceased and 600 living) from the AIDS prevention and control information system in the Wenzhou area from 2006 to 2018. Multivariable Cox proportional hazards regression models were formulated to estimate the effect of HB. The predictive performance improvement contributed by HB was evaluated using the C-index and net reclassification improvement.

KeywordC-index Hb Hiv/aids Associated Death Interaction Net Discrimination
DOI10.18632/aging.202987
URLView the original
Language英語English
WOS IDWOS:000651453900005
Scopus ID2-s2.0-85106605993
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorGuangyun Mao
Affiliation1.Wenzhou Center for Disease Control and Prevention, Wenzhou, 325000, China
2.Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, China
3.Faculty of Health Sciences, University of Macau, Macau, 999078, China
4.Center on Evidence-Based Medicine and Clinical Epidemiology, School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, China
5.The Sixth People’s Hospital of Wenzhou, Wenzhou, 325035, China
6.School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325000, China
7.The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China
8.The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310000, China
Recommended Citation
GB/T 7714
Dayong Wang,Xiangqing Hou,Xianghua Yu,et al. Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy[J]. Aging, 2021, 13(9), 13061-13072.
APA Dayong Wang., Xiangqing Hou., Xianghua Yu., Tao Wang., Zhenmiao Ye., Jushuang Li., Feifei Su., Chengnan Guo., Fang Peng., Shuzhen Zhao., Huihui Li., Jingjing Zuo., Dehua Su., Lina Zhao., Hemei Zhang., Xiangyang Chen., Ruoqiu Chen., Qipeng Xie., Chao Zheng., & Guangyun Mao (2021). Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy. Aging, 13(9), 13061-13072.
MLA Dayong Wang,et al."Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy".Aging 13.9(2021):13061-13072.
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