The LiS-based lithium–sulfur battery is an attractive option for next-generation energy storage, which can couple with Li-free anodes to reveal a feasible approach to circumvent the safety issue of the highly reactive lithium metal. However, bulk LiS needs a high activation potential with the electrolyte decomposition in the initial oxidation and shows uncontrollable polysulfides migration in the cycling. To address these challenges, a facile solvation strategy to fully dissolve bulk LiS is developed to achieve the only 0.2 V potential barrier without any hyperthermal treatments and/or additives. Meanwhile, the novel VB materials offer abundant active sites to confine polysulfide migration with the low self-lithiation property. With those ingenious tailoring of cell designs, the VB-based liquid LiS cell achieves a stable capacity (530 mAh/g with 2 mg/cm) at 1.0 C with an extremely low fading capacity (78% capacity retention) after 500 cycles. More importantly, this strategy provides a novel insight into the liquid LiS-based lithium–sulfur battery with a better performance for the commercial applications.