The aim of this study is to examine the longitudinal relationships between cyberbullying perpetration, mindfulness, and depression among Chinese adolescents. The participants in our study included 1390 high school students who were randomly selected from several secondary schools in east China. Participants completed the Chinese version of Revised Cyber Bullying Inventory-Cyberbullying Subscale, the Chinese version of the Mindfulness Attention Awareness Scale and the Centre for Epidemiologic Studies Depression Scale for Children at two time points (6-month interval). The results found that cyberbullying, mindfulness and depression would predict each other over time. Contributions to theory, limitations in our research and recommendations for future intervention are discussed in this article.