基于具有优异表面增强拉曼散射(SERS)性能的石墨烯隔离的金纳米晶(GIAN)能够在水-有机相界面自 组装, 待测物分子在有机相中的分配系数较大以及GIAN能够通过π⁃π相互作用与待测物分子结合的优势, 构 建了激光介导的待测物分子的高效富集策略, 进而实现了9,10-双苯乙炔基蒽(BPEA)分子的痕量SERS分析. 所构建的新型待测物分子高效富集策略在一定程度上避免了因“咖啡环效应”带来的信号波动, 有望为复杂体 系中痕量待测物的SERS分析提供可靠的平台.

Surface enhanced Raman scattering(SERS) technique has extensive application prospects in biochemical analysis and environmental monitoring field owing to its high sensitivity, low background inter- ference, superior anti-photobleaching and anti-photocarbonization capabilities, as well as ability to reflect the inherent molecular fingerprint information of the analyte. Non-target analytes are competitively adsorbed on the surface of the SERS substrate, making the analysis of trace analytes in complex systems extremely challenging. Based on the self-assemble of the graphene-isolated Au nanocrystal(GIAN) with excellent SERS performance at HO-Organic phase interface, the large partition coefficient of the analyte in organic phase, and GIAN can combine with the analyte via π-π interaction, a laser-mediated highly-efficient analyte enrichment strategy is proposed and trace SERS analysis of 9, 10-bis(phenylethynyl)anthracene(BPEA) molecules is eventually realized in this work. The proposed novel analyte enrichment strategy avoids the signal fluctuation caused by the "coffee ring effect" to a certain extent and is expected to provide a reliable platform for SERS analysis of trace analytes in complex systems.