Metal-organic frameworks (MOFs) possess large surface area, high porosity, tunable structures, and flexible tailored properties, enabling their use as adsorbents and sensors for food contamination. Specifically, MOFs have been regarded as promising materials in instrumental analysis of food contamination via separation and extraction of target analytes based on their high surface area with high adsorption capacity. Meanwhile, integrating LMOFs with a variety of loading guests or functional materials has been demonstrated as a viable strategy to extend the application of MOFs-based sensors for food contamination analysis. This review highlights the applications of MOFs in food contamination analysis. In particular, we will describe the mode of action of MOFs as sorbent material and sensors. Meanwhile, the potential application of MOFs for pre-treatment and sensing in food contamination analysis will be discussed. Finally, we offer our perspective on the application of MOFs based materials for food contamination analysis.