Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property

doi:10.1016/j.bioorg.2021.105426

UM > THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)

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	Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property
	Lou, Ruohan 1; Xu, Fan 3; Xu, Yunshao 1; Chen, Jiali 1; Feng, Zheling 1; Gan, Lishe 2,3; Lin, Ligen1
	2021-12-01
Source Publication	Bioorganic Chemistry
ISSN	0045-2068
Volume	117 Pages:105426
Abstract	A novel cassane-type diterpenoid, caesalpinaxin (1), was isolated from the seeds of Caesalpinia minax Hance. The structure of caesalpinaxin was established by means of spectroscopic techniques (NMR, HR-ESIMS, UV and IR). The absolute configuration of caesalpinaxin was determined by quantum chemical calculations of its theoretical electronic circular dichroism (ECD) spectrum. Caesalpinaxin is the first cassane-type diterpenoid with 21 carbons core skeleton, containing an unusual δ-lactone ring. A plausible biosynthetic pathway was proposed for compound 1. Furthermore, caesalpinaxin was tested for the pro-angiogenetic activity on human umbilical vein endothelial cells (HUVECs). The results indicated that this compound significantly stimulated migration and tuber formation through enhancing the level of vascular endothelial growth factor (VEGF). Thus, caesalpinaxin might be applied in accelerating wound healing.
Keyword	Angiogenesis Caesalpinaxin Cassalpinia Minax Ecd Fabaceae
DOI	10.1016/j.bioorg.2021.105426
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Biochemistry & Molecular Biology ; Chemistry
WOS Subject	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS ID	WOS:000711454100005
Scopus ID	2-s2.0-85117239631
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding Author	Gan, Lishe; Lin, Ligen
Affiliation	1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macao 2.School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China 3.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Lou, Ruohan,Xu, Fan,Xu, Yunshao,et al. Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property[J]. Bioorganic Chemistry, 2021, 117, 105426.
APA	Lou, Ruohan., Xu, Fan., Xu, Yunshao., Chen, Jiali., Feng, Zheling., Gan, Lishe., & Lin, Ligen (2021). Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property. Bioorganic Chemistry, 117, 105426.
MLA	Lou, Ruohan,et al."Caesalpinaxin, a cassane-type diterpenoid with a 21-carbon core skeleton from the seeds of Caesalpinia minax possessing pro-angiogenetic property".Bioorganic Chemistry 117(2021):105426.

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