How has Sub-Sahara Africa (SSA) experienced the COVID-19 pandemic? This article seeks to examine the challenges faced by a region that was earlier expected to be the epicenter of the pandemic. The study identifies three critical stages that pose challenges for governments and development partners operating in SSA trying to avoid mass infections and the subsequent negative socioeconomic impacts of the pandemic. First, the article begins by examining the challenges experienced in restraining the spread of COVID-19 such as the lack of adequate resources and technology to effectively pursue contact tracing, the dilemma of implementing lockdowns, and the impact of fake news. Second, the article looks at the challenges arising from technical and capacity elements of testing, treatment, and the development and access to vaccines. Finally, the study examines the potential obstacles to a smooth post-COVID-19 recovery. The author argues that although some positive actions have been taken by governments in SSA during the pandemic, the challenges that are emerging as a result of the direct and indirect impacts of the disease cannot be overlooked. The authors therefore offer several recommendations that can guide policy responses against pandemics in the short and long-run.