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Volume-based algorithm of lung dose optimization in novel dynamic arc radiotherapy for esophageal cancer
Lin, Kuan Heng1,2,3; Hsu, Chen Xiong1,2; Wang, Shan Ying1,4; Mok, Greta S.P.5; Chang, Chiu Han2; Tien, Hui Ju1,2; Shueng, Pei Wei2,6; Wu, Tung Hsin1
2021-02-23
Source PublicationScientific Reports
ISSN2045-2322
Volume11Pages:4360
Abstract

This study aims to develop a volume-based algorithm (VBA) that can rapidly optimize rotating gantry arc angles and predict the lung V preceding the treatment planning. This phantom study was performed in the dynamic arc therapy planning systems for an esophageal cancer model. The angle of rotation of the gantry around the isocenter as defined as arc angle (θ), ranging from 360° to 80° with an interval of 20°, resulting in 15 different θ of treatment plans. The corresponding predicted lung V was calculated by the VBA, the mean lung dose, lung V, lung V, mean heart dose, heart V, the spinal cord maximum dose and conformity index were assessed from dose–volume histogram in the treatment plan. Correlations between the predicted lung V and the dosimetric indices were evaluated using Pearson’s correlation coefficient. The results showed that the predicted lung V and the lung V in the treatment plan were positively correlated (r = 0.996, p < 0.001). As the θ decreased, lung V, lung V, and the mean lung dose decreased while the mean heart dose, V and the spinal cord maximum dose increased. The V and the mean lung dose also showed high correlations with the predicted lung V (r = 0.974, 0.999, p < 0.001). This study successfully developed an efficient VBA to rapidly calculate the θ to predict the lung V and reduce the lung dose, with potentials to improve the current clinical practice of dynamic arc radiotherapy.

DOI10.1038/s41598-021-83682-3
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000626729300018
PublisherNATURE PORTFOLIOHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
Scopus ID2-s2.0-85101707500
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionFaculty of Science and Technology
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorShueng, Pei Wei; Wu, Tung Hsin
Affiliation1.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
2.Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
3.Industrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
4.Department of Nuclear Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
5.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao
6.Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Recommended Citation
GB/T 7714
Lin, Kuan Heng,Hsu, Chen Xiong,Wang, Shan Ying,et al. Volume-based algorithm of lung dose optimization in novel dynamic arc radiotherapy for esophageal cancer[J]. Scientific Reports, 2021, 11, 4360.
APA Lin, Kuan Heng., Hsu, Chen Xiong., Wang, Shan Ying., Mok, Greta S.P.., Chang, Chiu Han., Tien, Hui Ju., Shueng, Pei Wei., & Wu, Tung Hsin (2021). Volume-based algorithm of lung dose optimization in novel dynamic arc radiotherapy for esophageal cancer. Scientific Reports, 11, 4360.
MLA Lin, Kuan Heng,et al."Volume-based algorithm of lung dose optimization in novel dynamic arc radiotherapy for esophageal cancer".Scientific Reports 11(2021):4360.
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