A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

doi:10.1038/srep22458

UM > Faculty of Health Sciences > DEPARTMENT OF PHARMACEUTICAL SCIENCES

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	A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α
	Lihua Lu 1; Modi Wang 1; Zhifeng Mao 1; Tian-Shu Kang2 ; Xiu-Ping Chen2 ; Jin-Jian Lu2 ; Chung-Hang Leung2 ; Dik-Lung Ma 1
	2016-03-02
Source Publication	Scientific Reports
ISSN	20452322
Volume	6
Other Abstract	A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.
DOI	10.1038/srep22458
URL	View the original
Indexed By	SCIE
WOS Research Area	Science & Technology - Other Topics
WOS Subject	Multidisciplinary Sciences
WOS ID	WOS:000371152600001
Scopus ID	2-s2.0-84959545602
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding Author	Dik-Lung Ma
Affiliation	1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Recommended Citation GB/T 7714	Lihua Lu,Modi Wang,Zhifeng Mao,et al. A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α[J]. Scientific Reports, 2016, 6.
APA	Lihua Lu., Modi Wang., Zhifeng Mao., Tian-Shu Kang., Xiu-Ping Chen., Jin-Jian Lu., Chung-Hang Leung., & Dik-Lung Ma (2016). A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α. Scientific Reports, 6.
MLA	Lihua Lu,et al."A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α".Scientific Reports 6(2016).

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