| Residential College | false |
| Status | 已發表Published |
| Inhibition of Janus kinase 2 by cyclometalated rhodium complexes | |
Leung C.-H.1,2  ; Yang H.3; Ma V.P.-Y.3; Chan D.S.-H.3; Zhong H.-J.1,2 ; Li Y.-W.4; Fong W.-F.4; Ma D.-L.3
| |
| 2012 | |
| Source Publication | MedChemComm
 |
| ISSN | 20402511 20402503 |
| Volume | 3Issue:6Pages:696-698 |
| Abstract | Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2. |
| DOI | 10.1039/c2md00306f |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| WOS ID | WOS:000304659600010 |
| Scopus ID | 2-s2.0-84865851117 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Leung C.-H.; Ma D.-L. |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China 2.Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China 3.Department of Chemistry, Hong Kong Baptist University, Hong Kong, China 4.Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China |
| First Author Affilication | University of Macau; Institute of Chinese Medical Sciences |
| Corresponding Author Affilication | University of Macau; Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Leung C.-H.,Yang H.,Ma V.P.-Y.,et al. Inhibition of Janus kinase 2 by cyclometalated rhodium complexes[J]. MedChemComm, 2012, 3(6), 696-698. |
| APA | Leung C.-H.., Yang H.., Ma V.P.-Y.., Chan D.S.-H.., Zhong H.-J.., Li Y.-W.., Fong W.-F.., & Ma D.-L. (2012). Inhibition of Janus kinase 2 by cyclometalated rhodium complexes. MedChemComm, 3(6), 696-698. |
| MLA | Leung C.-H.,et al."Inhibition of Janus kinase 2 by cyclometalated rhodium complexes".MedChemComm 3.6(2012):696-698. |
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