| Residential College | false |
| Status | 已發表Published |
| Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors | |
| Leung C.-H.1; Chan D.S.-H.1; Kwan M.H.-T.1; Cheng Z.1; Wong C.-Y.2; Zhu G.-Y.1; Fong W.-F.1; Ma D.-L.1 | |
| 2011-05-02 | |
| Source Publication | ChemMedChem
 |
| ISSN | 18607179 18607187 |
| Volume | 6Issue:5Pages:765-768 |
| Abstract | Old dogs, new tricks! We applied structure-based virtual screening methods to identify small-molecule inhibitors of tumor necrosis factor-α (TNF-α) from a database of 3000 US Food and Drug Administration (FDA)-approved drugs. Darifenacin (Enablex) and ezetimibe (Zetia) were identified as direct TNF-α inhibition, representing only the fifth and sixth examples of small-molecule TNF-α inhibitors. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keyword | Approved Drugs Drug Discovery Inhibitors Tumor Necrosis Factor Virtual Screening |
| DOI | 10.1002/cmdc.201100016 |
| URL | View the original |
| Language | 英語English |
| WOS ID | WOS:000289860900002 |
| Scopus ID | 2-s2.0-79955032758 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Hong Kong Baptist University 2.City University of Hong Kong |
| Recommended Citation GB/T 7714 | Leung C.-H.,Chan D.S.-H.,Kwan M.H.-T.,et al. Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors[J]. ChemMedChem, 2011, 6(5), 765-768. |
| APA | Leung C.-H.., Chan D.S.-H.., Kwan M.H.-T.., Cheng Z.., Wong C.-Y.., Zhu G.-Y.., Fong W.-F.., & Ma D.-L. (2011). Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors. ChemMedChem, 6(5), 765-768. |
| MLA | Leung C.-H.,et al."Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors".ChemMedChem 6.5(2011):765-768. |
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