English | 繁體
UM
Residential Collegefalse
Status已發表Published
Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes
Wang P.1; Leung C.-H.1; Ma D.-L.1; Sun R.W.-Y.1; Yan S.-C.1; Chen Q.-S.1; Che C.-M.1
2011-03-07
Source PublicationAngewandte Chemie - International Edition
ISSN14337851 15213773
Volume50Issue:11Pages:2554-2558
Abstract

In the groove: The unique major-groove-binding properties of a Pt complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KeywordBioinorganic Chemistry Dna Recognition Metallodrugs Platinum Transcription Factors
DOI10.1002/anie.201006887
URLView the original
Language英語English
WOS IDWOS:000288037600019
Scopus ID2-s2.0-79952263626
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
2.Hong Kong Baptist University
Recommended Citation
GB/T 7714		 Wang P.,Leung C.-H.,Ma D.-L.,et al. Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes[J]. Angewandte Chemie - International Edition, 2011, 50(11), 2554-2558.
APA Wang P.., Leung C.-H.., Ma D.-L.., Sun R.W.-Y.., Yan S.-C.., Chen Q.-S.., & Che C.-M. (2011). Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes. Angewandte Chemie - International Edition, 50(11), 2554-2558.
MLA Wang P.,et al."Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes".Angewandte Chemie - International Edition 50.11(2011):2554-2558.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang P.]'s Articles
[Leung C.-H.]'s Articles
[Ma D.-L.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang P.]'s Articles
[Leung C.-H.]'s Articles
[Ma D.-L.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang P.]'s Articles
[Leung C.-H.]'s Articles
[Ma D.-L.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.