Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents

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	Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents
	Linden A.-M.1; Vaisanen J.1; Lakso M.1; Nawa H.2; Wong G.1 ; Castren E.1
	2000-06-27
Source Publication	Journal of Molecular Neuroscience
ISSN	08958696
Volume	14 Issue:1-2 Pages:27-37
Abstract	We have investigated the potential role of neurotrophic factors in antipsychotic drug action by examining the effects of antipsychotic and psychotropic treatments on the mRNA expression of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and their receptors, trkB and trkC, respectively, in rat brain. Neither acute nor chronic clozapine treatment significantly affected the expression of these mRNAs in any brain area investigated, except for a decrease in trkB expression in the granule cells of the olfactory bulb. We then examined the effects of the psychotropic agent MK-801. MK-801 (5 mg/kg; 4 h) significantly increased BDNF mRNA in the entorhinal cortex, but did not influence NT-3, trkB, or trkC expression in any brain area except for the olfactory bulb. The induction of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 mg/kg), but not with the antidepressant desipramine (15 mg/kg). Finally, we confirmed that the effects of MK-801 on BDNF mRNA were reflected in the respective changes in BDNF protein levels: MK-801 significantly increased anti-BDNF reactivity in the entorhinal cortex (126 ± 7% of control) while concomitantly decreasing in the hippocampus (71 ± 2% of control). These data do not support the hypothesis that neurotrophins play an important role in antipsychotic drug action, but rather suggest that induction of BDNF in the entorhinal cortex may play a significant role in the psychotropic action of MK-801.
Keyword	BDNF Clozapine Entorhinal cortex Haloperidol MK-801 NT-3 TrkB TrkC
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	Faculty of Health Sciences
Affiliation	1.Itä-Suomen yliopisto 2.Niigata University
Recommended Citation GB/T 7714	Linden A.-M.,Vaisanen J.,Lakso M.,et al. Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents[J]. Journal of Molecular Neuroscience, 2000, 14(1-2), 27-37.
APA	Linden A.-M.., Vaisanen J.., Lakso M.., Nawa H.., Wong G.., & Castren E. (2000). Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents. Journal of Molecular Neuroscience, 14(1-2), 27-37.
MLA	Linden A.-M.,et al."Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents".Journal of Molecular Neuroscience 14.1-2(2000):27-37.

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