Molecular effects of the psychotropic NMDA receptor antagonist MK-801 in the rat entorhinal cortex: Increases in AP-1 DNA binding activity and expression of Fos and Jun family members

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	Molecular effects of the psychotropic NMDA receptor antagonist MK-801 in the rat entorhinal cortex: Increases in AP-1 DNA binding activity and expression of Fos and Jun family members
	Kontkanen O.; Lakso M.; Koponen E.; Wong G.; Castren E.
	2000
Source Publication	Annals of the New York Academy of Sciences
Volume	911
Pages	73-82
Abstract	Noncompetitive NMDA receptor antagonists such as phencyclidine and MK-801 produce psychotropic symptoms that closely resemble schizophrenic psychosis and induce the expression of immediate early genes in limbic cortical areas. We are concentrating on analyzing molecular and physiological effects that these drugs produce in the entorhinal cortex and on the potential connection between these effects and the psychotic symptoms. We show here that MK-801 increases the DNA binding activity of the activator protein-1 (AP-1) complex in the entorhinal cortex. We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c-Fos, FosB, Fra-2, and JunB, as well as Fos family proteins in the entorhinal cortex after MK-801 administration. This suggests that the activated AP-1 complex consists of these transcription factors. Genes regulated by the AP-1 complex in the entorhinal cortex might he involved in the pathophysiology of psychotic behavior and are potential targets for new antipsychotic drugs.
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Conference paper
Collection	Faculty of Health Sciences
Affiliation	Itä-Suomen yliopisto
Recommended Citation GB/T 7714	Kontkanen O.,Lakso M.,Koponen E.,et al. Molecular effects of the psychotropic NMDA receptor antagonist MK-801 in the rat entorhinal cortex: Increases in AP-1 DNA binding activity and expression of Fos and Jun family members[C], 2000, 73-82.
APA	Kontkanen O.., Lakso M.., Koponen E.., Wong G.., & Castren E. (2000). Molecular effects of the psychotropic NMDA receptor antagonist MK-801 in the rat entorhinal cortex: Increases in AP-1 DNA binding activity and expression of Fos and Jun family members. Annals of the New York Academy of Sciences, 911, 73-82.

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